Brand Name Of Enalapril

Introduction to Enalapril

Enalapril is a widely used medication primarily prescribed for the treatment of hypertension and heart failure. It functions as an angiotensin-converting enzyme (ACE) inhibitor, which helps to relax blood vessels and reduce blood pressure by inhibiting the formation of angiotensin II, a potent vasoconstrictor.

Common Brand Names of Enalapril

Renitec

One of the most recognized brand names for enalapril is Renitec, which is manufactured by MSD (Merck Sharp & Dohme) in the Netherlands. Renitec has been extensively studied and is often used as a reference product in bioequivalence studies.

Narapril

Another brand of enalapril is Narapril, produced by Julphar in the UAE. Studies have shown that Narapril is bioequivalent to Renitec, meaning it has similar pharmacokinetic properties and efficacy. This was demonstrated in a study involving 24 healthy volunteers, where both brands showed comparable pharmacokinetic profiles, including parameters like AUC (Area Under the Curve), Cmax (maximum concentration), and Tmax (time to reach maximum concentration).

Bioequivalence and Efficacy

Bioequivalence Studies

Bioequivalence studies are crucial for ensuring that different brands of the same medication provide the same therapeutic effect. In the case of enalapril, a study comparing Narapril and Renitec found no significant differences in their pharmacokinetic parameters. This indicates that both brands are equally effective in delivering the active ingredient, enalaprilat, into the bloodstream.

In Vitro Quality Tests

Further comparative evaluations of different marketed brands of enalapril maleate tablets have confirmed that both high-cost and low-cost brands meet pharmacopoeial standards. Tests for weight variation, hardness, friability, disintegration time, and dissolution were conducted, and both brands passed these tests, indicating that they contain equal quantities of the active pharmaceutical ingredient (API) and exhibit similar actions.

Conclusion

Enalapril is available under various brand names, with Renitec and Narapril being two prominent examples. Studies have shown that these brands are bioequivalent, ensuring that they provide the same therapeutic benefits. This makes it easier for healthcare providers to prescribe enalapril with confidence, knowing that different brands will offer consistent efficacy and safety .

Brand name of enalapril

Summary

Not a yes or no question