400 mg caffeine at once

Introduction

Caffeine is a widely consumed psychoactive substance with various effects on human health and performance. The ingestion of 400 mg of caffeine, which is considered a high dose, has been studied in different contexts, including pain management, cognitive function, calcium economy, and physical performance.

Key Insights

A combination of ibuprofen 400 mg and caffeine 100 mg is effective for treating dental pain, suggesting a potential synergistic effect between caffeine and analgesics.
High doses of caffeine (400 mg) can enhance vigilance and executive control of visual attention in habitual consumers, indicating caffeine's potential to improve cognitive function.
Moderate caffeine intake (400 mg/day) does not significantly affect calcium absorption, bone remodeling, or calcium pool turnover in premenopausal women, suggesting that caffeine at this dose does not adversely impact bone health.
Daily caffeine intake up to 400 mg is not associated with general toxicity, cardiovascular effects, effects on bone status and calcium balance, changes in adult behavior, increased incidence of cancer, or effects on male fertility in healthy adults.
Single doses of caffeine up to 200 mg are considered safe for the general population, and habitual consumption up to 400 mg per day does not raise safety concerns for non-pregnant adults.
The pharmacokinetic properties of ibuprofen are not significantly affected by the addition of caffeine, indicating that caffeine does not alter the absorption of ibuprofen when combined in a fixed-dose.
Ingestion of 400 mg of caffeine does not significantly change the performance of untrained subjects in simulated microsurgical tasks, suggesting that this dose does not impair fine motor control.
Regular consumption of caffeine up to 400 mg daily from the age of 18 is considered safe for healthy adults, with most people consuming within this safe range.
Caffeine dosages of 400 mg can affect latencies in visual target scanning tasks differently based on individual caffeine consumption rates, with habitual low consumers showing higher latencies compared to high consumers.

Conclusion

The ingestion of 400 mg of caffeine has been shown to have various effects, including improved pain management when combined with ibuprofen, enhanced cognitive function, and no significant impact on bone health or fine motor control. While this dose is generally considered safe for healthy adults, individual responses can vary, particularly in cognitive tasks, depending on habitual caffeine consumption rates. Overall, moderate daily caffeine intake at this level is not associated with adverse health effects.

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400 mg caffeine at once

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Efficacy and safety of a fixed‐dose combination of ibuprofen and caffeine in the management of moderate to severe dental pain after third molar extraction

The combination of ibuprofen 400 mg and caffeine 100 mg effectively reduces moderate to severe dental pain after third molar extraction, with no significant side effects compared to ibuprofen 400 mg monotherapy, caffeine, and placebo.

Acute caffeine consumption enhances the executive control of visual attention in habitual consumers

High doses of caffeine (400 mg) can enhance vigilance and executive control of visual attention in habitual consumers, but only at the highest administered dose.

Effects of moderate caffeine intake on the calcium economy of premenopausal women.

Moderate caffeine intake (400 mg/d) does not significantly affect calcium absorption, fecal calcium, or urine calcium levels in premenopausal women, but may slightly alter bone remodeling.

Effects of caffeine on human health

Moderate daily caffeine intake up to 400 mg for healthy adults is not associated with adverse effects, while reproductive-aged women and children require specific advice on limiting intake.

Scientific Opinion on the safety of caffeine

Single doses up to 200 mg and habitual consumption up to 400 mg per day do not pose safety concerns for healthy adults, while pregnant women and lactating women do not face concerns for breastfed infants.

Pharmacokinetic Properties of Ibuprofen (IBU) From the Fixed‐Dose Combination IBU/Caffeine (400/100 mg; FDC) in Comparison With 400 mg IBU as Acid or Lysinate Under Fasted and Fed Conditions—Data From 2 Single‐Center, Single‐Dose, Randomized Crossover Studies in Healthy Volunteers

The fixed-dose combination of ibuprofen acid 400 mg and caffeine 100 mg has similar pharmacokinetic properties to ibuprofen acid alone, but ibuprofen lysinate has no advantage under real-life conditions.

The Effect of 400 mg of Caffeine on Untrained Subjects Performance of Simulated Ocular Microsurgery

No significant change in simulated microsurgical ability was observed after 400 mg of caffeine ingestion in previously untrained students.

Caffeine – stimulating and aromatic: but safe!

Caffeine consumption up to 400 mg daily for healthy adults and 200 mg for pregnant and breastfeeding women is considered safe, with 95% of those questioned within the safe range.

Caffeine Consumption and Target Scanning Performance

Higher caffeine dosages (400 mg) lead to longer target scanning latencies in low coffee consumption rate individuals, but no significant differences in correct detection percentages were found between the two groups.

Caffeine Consumption in Switzerland: Results from the First National Nutrition Survey MenuCH

Swiss adults consume an average of 191 mg/day of caffeine, with coffee (83%), tea (9%), and soft drinks (4%), with caffeine consumption peaking between 06:00 and 09:00 (29%) and varying across age groups and linguistic regions.

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