Can crestor cause liver damage
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Can Crestor Cause Liver Damage?
Introduction to Crestor and Liver Health
Crestor, a widely used lipid-lowering agent, has been under scrutiny for its potential side effects, including liver damage. Understanding the risks associated with Crestor is crucial for both patients and healthcare providers.
FDA Concerns and Safety Evaluations
The safety of Crestor has been challenged by FDA epidemiologists, highlighting concerns about its potential to cause liver damage. In testimony before a Senate committee, Dr. David Graham, an FDA epidemiologist, included Crestor among five drugs whose safety was questioned2. This scrutiny underscores the importance of monitoring liver function in patients taking Crestor.
Case Reports and Clinical Observations
While there are no direct case reports linking Crestor specifically to liver damage in the provided data, the broader context of drug safety evaluations by the FDA includes concerns about liver injury with other drugs in the same category. For instance, the diabetes drug Rezulin was removed from the market due to liver failure, indicating that drugs affecting metabolism and lipid levels can have serious hepatic side effects2.
Conclusion
Although the provided data does not include specific cases of liver damage directly attributed to Crestor, the FDA's scrutiny and the inclusion of Crestor in safety evaluations suggest a need for caution. Patients on Crestor should have their liver function monitored regularly to mitigate potential risks. Always consult with a healthcare provider for personalized medical advice.
Sources and full results
Most relevant research papers on this topic
A case of CREST syndrome with rapidly progressive liver damage.
CREST syndrome can be associated with rapidly progressive liver damage, suggesting a potential link between autoimmune chronic active hepatitis and CREST syndrome.
Case ReportEvaluating the safety of diabetes drugs: perspective of a Food and Drug Administration insider.
FDA's safety evaluation of diabetes drugs is based on data from thousands of patients, but it is difficult to draw firm conclusions about their safety based on a few thousand patients in clinical trials.
Rigorous JournalDrug-induced liver injury
Drug-induced liver injury (DILI) occurs when drugs (pharmacological therapies, traditional medicines, and herbal or dietary supplements) cause liver damage.
Highly CitedRosuvastatin
Rosuvastatin effectively and rapidly improves lipid profiles in patients with a broad spectrum of dyslipidemias, with higher effectiveness in those with hypercholesterolemia.
Highly CitedCreatine Alleviates Doxorubicin-Induced Liver Damage by Inhibiting Liver Fibrosis, Inflammation, Oxidative Stress, and Cellular Senescence
Creatine supplementation can protect against doxorubicin-induced liver damage by reducing liver fibrosis, inflammation, oxidative stress, and cellular senescence.
RCT
Animal Study
Very Rigorous JournalRosuvastatin (Crestor) and rhabdomyolysis
Reason for posting: Rosuvastatin (Crestor) is a relatively new cholesterol-lowering drug that has become one of the top-selling new pharmaceuticals since it was first marketed in Canada in February 2003. However, Health Canada recently alerted health care professionals of reports of rhabdomyolysis
Outcome of acute idiosyncratic drug‐induced liver injury: Long‐term follow‐up in a hepatotoxicity registry
Cholestatic/mixed liver damage is more likely to become chronic, with cardiovascular and central nervous system drugs being the main groups leading to chronic liver damage.
Observational StudyHighly CitedIs pharmaceutical detailing informative? Evidence from contraindicated drug prescriptions
Pharmaceutical detailing significantly reduces physicians' likelihood of prescribing Crestor to contraindicated patients, potentially impacting prescribing patterns.
Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice
Genetic ablation of mTOR in mouse livers does not protect against acetaminophen-induced liver injury but may slightly improve liver regeneration and mouse survival after APAP overdose.
Non-RCTAnimal StudyAdverse drug reaction: rosuvastatin as a cause for ischaemic colitis in a 64-year-old woman
Rosuvastatin can cause rare but serious adverse drug reactions, such as ischaemic colitis, in 64-year-old women with hypercholesterolaemia.
Case Report