Can high cholesterol cause dizziness
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Can High Cholesterol Cause Dizziness?
Introduction to High Cholesterol and Its Effects
High cholesterol, particularly elevated low-density lipoprotein (LDL) cholesterol, is a well-known risk factor for cardiovascular diseases. It can lead to various health complications, including heart attacks and strokes. However, the relationship between high cholesterol and symptoms like dizziness is less commonly discussed.
Dizziness as a Side Effect of Cholesterol-Lowering Treatments
Combined Therapy and Dizziness
In a study involving 12,705 participants at intermediate risk of cardiovascular disease, a combination therapy of rosuvastatin, candesartan, and hydrochlorothiazide was found to significantly reduce cardiovascular events compared to a placebo. However, this combined therapy was also associated with an increased incidence of dizziness among participants . This suggests that while the treatment effectively lowers cholesterol and blood pressure, it may also contribute to dizziness as a side effect.
Evinacumab and Dizziness
Evinacumab, a monoclonal antibody used to treat homozygous familial hypercholesterolemia (HoFH), has also been associated with dizziness. Clinical trials have shown that while evinacumab significantly reduces LDL cholesterol levels, common adverse events include dizziness, along with other symptoms like nasopharyngitis and influenza-like illness. This indicates that dizziness can be a side effect of certain cholesterol-lowering medications.
Familial Hypercholesterolemia and Dizziness
Case Study of Familial Hypercholesterolemia
A case study of a family with a history of familial hypercholesterolemia (FH) reported instances of cerebral infarction (CI) across three generations. One of the family members, a 77-year-old female, experienced dizziness due to cerebellar lacunae, which was linked to elevated cholesterol levels. This case highlights that high cholesterol can contribute to conditions that may cause dizziness, particularly in individuals with FH.
Conclusion
While high cholesterol itself is not directly linked to causing dizziness, the treatments for lowering cholesterol and the complications arising from conditions like familial hypercholesterolemia can lead to dizziness. It is important for patients undergoing cholesterol-lowering treatments to be aware of this potential side effect and to consult their healthcare providers if they experience dizziness. Monitoring and managing cholesterol levels remain crucial to reducing the risk of cardiovascular events and associated symptoms.
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