Can i take lisinopril twice a day
Pro Research Analysisby 
Searched over 200M research papers
Can I Take Lisinopril Twice a Day?
Twice-Daily vs. Once-Daily Lisinopril for Hypertension
Blood Pressure Control
Research comparing twice-daily (BID) and once-daily (QDay) dosing of lisinopril for hypertension has shown mixed results. A retrospective cohort study found that while twice-daily administration was associated with a greater reduction in systolic blood pressure compared to once-daily dosing, the differences in diastolic blood pressure were not statistically significant. Another study indicated no significant differences in systolic or diastolic blood pressure between the two dosing regimens, suggesting that both dosing schedules are similarly effective in managing blood pressure.
Safety and Adverse Events
Safety profiles between the two dosing regimens also show some differences. The same retrospective cohort study noted an increased risk of angioedema with twice-daily dosing of lisinopril compared to once-daily dosing. This suggests that while twice-daily dosing may offer some benefits in blood pressure reduction, it could come with an increased risk of certain adverse events.
Twice-Daily Lisinopril for Congestive Heart Failure
Efficacy in Heart Failure
In patients with congestive heart failure (CHF), studies have compared the efficacy of once-daily and twice-daily dosing of lisinopril. One study found that both dosing regimens significantly improved exercise tolerance and left ventricular ejection fraction, with no significant differences between the two. Another study suggested that twice-daily administration might have better effects on neurohumoral factors, such as lower plasma norepinephrine levels, which could be beneficial for patients with CHF.
Comparison with Other ACE Inhibitors
When compared to other ACE inhibitors like captopril, lisinopril administered once daily was found to be at least as effective and well-tolerated as captopril administered twice daily in improving exercise tolerance and heart function in CHF patients . This indicates that lisinopril, whether taken once or twice daily, is a viable option for managing CHF.
Conclusion
While twice-daily dosing of lisinopril may offer some advantages in blood pressure reduction and neurohumoral effects in CHF, it also comes with an increased risk of adverse events like angioedema. For hypertension, the overall effectiveness of once-daily and twice-daily dosing appears to be similar. Therefore, the decision to take lisinopril twice a day should be made in consultation with a healthcare provider, considering the specific health needs and risk factors of the patient.
Sources and full results
Most relevant research papers on this topic