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These studies suggest that diabetes can contribute to mortality, particularly through complications and in specific populations, although overall mortality rates have declined in some groups.
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Diabetes, both type 1 and type 2, significantly impacts mortality rates. Research indicates that individuals with diabetes have higher mortality rates compared to those without the condition. For instance, a comprehensive review of randomized controlled trials (RCTs) involving type 2 diabetes patients revealed a wide range of annual mortality rates, from 0.28 to 8.24 per 100 patient-years, with higher rates associated with older age, longer diabetes duration, and comorbid conditions like hypertension and chronic kidney disease. Similarly, a systematic review of trends in all-cause mortality among people with diabetes showed that while mortality rates have generally declined over the years, they remain higher in diabetic populations compared to non-diabetic ones.
Age plays a crucial role in diabetes-related mortality. Studies have shown that older adults diagnosed with diabetes have a higher risk of mortality. For example, a review focusing on older individuals with type 2 diabetes found that diabetes significantly contributes to mortality and reduced life expectancy in this demographic. Another study estimated that diabetes contributed to 11.3% of deaths globally among adults aged 20-79 years, with a notable proportion of these deaths occurring in individuals under 60 years old.
Gender differences also influence mortality rates in diabetes. Research has shown that women with type 1 diabetes have a roughly 40% greater excess risk of all-cause mortality compared to men with the same condition. This increased risk is even more pronounced for fatal and nonfatal vascular events. Additionally, a study on the Early Treatment Diabetic Retinopathy Study (ETDRS) participants found that complications like amputation and poor visual acuity were strong predictors of mortality in type 1 diabetes, while macrovascular disease and worsening nephropathy, neuropathy, and retinopathy were significant predictors in type 2 diabetes.
Over the past few decades, there have been significant reductions in diabetes-related mortality, particularly in high-income countries. A systematic review of trends in all-cause mortality among people with diabetes found that mortality rates declined in 80% of populations with diabetes in the 1980s, 53% in the 1990s, and 85% from 2000 onwards. However, these declines were more pronounced in Europid populations compared to non-Europid populations. Another study analyzing data from the National Health Interview Survey Linked Mortality files from 1985 to 2015 reported a 20% decline in all-cause death rates every 10 years among US adults with diabetes, with significant reductions in deaths from vascular causes and cancers.
In conclusion, diabetes is a significant contributor to mortality, with higher rates observed in older adults, women, and those with comorbid conditions. While there have been improvements in mortality rates over the years, diabetes remains a critical health issue that requires ongoing management and prevention efforts to reduce its impact on life expectancy.
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