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Some studies suggest that high-normal blood pressure increases the risk of cardiovascular disease, while other studies indicate that normal blood pressure is associated with a lower risk of heart failure.
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While high blood pressure is a well-known risk factor for cardiovascular diseases, including heart attacks, individuals with normal blood pressure are not entirely free from risk. Research indicates that even those with blood pressure levels considered normal can still experience cardiovascular events, including heart attacks. For instance, a study involving young adults found that those with normal blood pressure had an increased risk of cardiovascular events compared to those with optimal blood pressure.
The term "high-normal blood pressure" refers to systolic pressure between 130-139 mm Hg and diastolic pressure between 85-89 mm Hg. Studies have shown that individuals with high-normal blood pressure have a significantly higher risk of cardiovascular diseases compared to those with optimal blood pressure. For example, the Framingham Heart Study revealed that high-normal blood pressure is associated with a higher incidence of cardiovascular disease, with a 10-year cumulative incidence of 4% for women and 8% for men aged 35-64 years .
Prehypertension, defined as blood pressure levels between 120/80 mm Hg and 139/89 mm Hg, also poses a risk for cardiovascular diseases. Research involving middle-aged adults demonstrated that individuals with prehypertensive levels of blood pressure have an increased risk of developing cardiovascular disease compared to those with optimal levels. This risk is particularly pronounced among certain subgroups, such as blacks, diabetics, and individuals with high body mass index (BMI).
Biologically, what is often considered "normal" blood pressure in clinical practice may still be higher than the optimal levels needed to minimize cardiovascular risk. Studies suggest that a right-sided shift in the population distribution of blood pressure is a primary cause of cardiovascular diseases. This shift implies that even within the range of normal blood pressure, there is a continuous and graded relationship with cardiovascular risk, including heart failure and coronary heart disease.
In summary, while having normal blood pressure reduces the risk of cardiovascular events compared to high blood pressure, it does not eliminate the risk entirely. Individuals with normal or high-normal blood pressure still face a significant risk of heart attacks and other cardiovascular diseases. Therefore, maintaining optimal blood pressure levels and monitoring other risk factors is crucial for cardiovascular health.
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