Can you get high on gabapentin
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Can You Get High on Gabapentin?
Gabapentin Misuse and Abuse
Gabapentin, originally prescribed for seizures and neuropathic pain, has seen a significant rise in misuse and abuse. Despite its therapeutic benefits, gabapentin is increasingly being used recreationally, often in doses higher than prescribed or without a prescription altogether1 2 3. The prevalence of misuse varies, with reports indicating that 1% of the general population, 40-65% of individuals with prescriptions, and 15-22% of opioid abusers misuse gabapentin1.
Recreational Use and Euphoria
One of the primary motivations behind gabapentin misuse is its ability to induce euphoria, especially at high doses. Users have reported experiences similar to those produced by opioids, benzodiazepines, and psychedelics1 2. This euphoric effect is a significant factor driving its recreational use, often in combination with other substances like opioids, benzodiazepines, and alcohol1 3.
Risk Factors and Populations at Risk
Individuals with a history of drug abuse are particularly prone to gabapentin misuse. The drug is often used to self-medicate, alleviate opioid withdrawal symptoms, or enhance the effects of other drugs like methadone1 3 4. The misuse of gabapentin is not limited to any specific demographic but is notably prevalent among those with existing substance abuse issues1 4.
Side Effects and Contraindications
Gabapentin misuse can lead to several adverse effects, including teratogenicity, hypoventilation, respiratory failure, and myopathy3. It is contraindicated in conditions such as myasthenia gravis and myoclonus, highlighting the importance of cautious prescription and monitoring3.
Global Concerns and Regulatory Actions
The misuse of gabapentin has raised global concerns, leading to its reclassification in the United Kingdom and several U.S. states2. The drug's potential for abuse has prompted regulatory bodies to consider stricter controls and monitoring to prevent diversion and misuse2 4.
Conclusion
Gabapentin, while beneficial for its intended medical uses, has a significant potential for misuse and abuse, particularly among individuals with a history of substance abuse. Its ability to induce euphoria at high doses makes it a target for recreational use, necessitating careful prescription practices and regulatory oversight to mitigate the risks associated with its misuse.
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Most relevant research papers on this topic
Gabapentin misuse, abuse and diversion: a systematic review.
Gabapentin misuse is prevalent globally, with substance abuse populations at a higher risk for misuse/abuse, primarily for recreational purposes and self-medication.
Systematic Review
Rigorous Journal
Highly CitedGabapentin: Change is in the Wind.
Gabapentin's widespread recreational abuse and potential diversion warrants reclassification in the United Kingdom and several U.S. states.
Review about gabapentin misuse, interactions, contraindications and side effects
Gabapentin is a potential drug of abuse for recreational use, opioid withdrawal, and methadone effects, with potential interactions and side effects.
Systematic ReviewRigorous JournalHighly CitedMisuse and Abuse of Pregabalin and Gabapentin: Cause for Concern?
Pregabalin and gabapentin have a potential for misuse, with increasing prescriptions and fatalities, and physicians should carefully evaluate potential drug abuse history and identify signs of misuse.
Rigorous JournalHighly CitedMisuse of the γ-aminobutyric acid analogues baclofen, gabapentin and pregabalin in the UK.
Misuse of GABA analogues (baclofen, gabapentin, and pregabalin) is prevalent in the UK, with online pharmacies being a significant source of supply for misuse.
Observational StudyRigorous JournalHighly CitedA Proof-of-Concept Randomized Controlled Study of Gabapentin: Effects on Cannabis Use, Withdrawal and Executive Function Deficits in Cannabis-Dependent Adults
Gabapentin shows potential in reducing cannabis use, withdrawal symptoms, and improving executive function in cannabis-dependent adults.
RCTRigorous JournalHighly CitedA Qualitative Analysis of Gabapentin Misuse and Diversion Among People Who Use Drugs in Appalachian Kentucky
Gabapentin is a prominent drug of abuse among opioid-using individuals in Appalachian Kentucky, with low cost and increasing popularity.
Observational StudyHow addictive are gabapentin and pregabalin? A systematic review
Gabapentinoids show limited addictive power, with pregabalin being more addictive, and should be avoided or administered with caution in patients with substance use disorders.
Systematic ReviewHighly CitedGabapentin for the treatment of alcohol use disorder
Gabapentin shows potential as a safe and effective treatment for alcohol use disorder, with unique benefits for alcohol-related insomnia and negative affect compared to existing treatments.
Systematic ReviewHighly CitedAbuse and Misuse of Pregabalin and Gabapentin
Gabapentinoids have potential for abuse, particularly in individuals with a history of opioid abuse, and prescribers should be aware of high-risk populations and monitor for signs of abuse.
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