Can you take ibuprofen with lisinopril
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Can You Take Ibuprofen with Lisinopril?
Drug-Drug Interactions: Ibuprofen and Lisinopril
Overview of Drug-Drug Interactions
Drug-drug interactions occur when the effects of one drug are altered by the presence of another. This is particularly important in the context of over-the-counter (OTC) medications and prescribed drugs, as these interactions can lead to reduced efficacy or increased risk of adverse effects. A study analyzing 448 prescriptions from various hospitals and clinics identified ibuprofen and lisinopril as one of the most common drug-drug interactions.
Impact on Blood Pressure Control
Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can interfere with the blood pressure-lowering effects of antihypertensive medications. A controlled trial involving 88 hypertensive patients found that ibuprofen significantly increased systolic blood pressure in patients taking a combination of lisinopril and hydrochlorothiazide. Specifically, ibuprofen elevated systolic blood pressure by 7.7-9.9%, which is a considerable increase that could undermine the effectiveness of the antihypertensive treatment.
Mechanism of Interaction
The interaction between ibuprofen and lisinopril is primarily due to the opposing effects they have on kidney function and blood pressure regulation. Lisinopril, an ACE inhibitor, works by relaxing blood vessels and reducing blood pressure. In contrast, ibuprofen can cause the kidneys to retain sodium and water, leading to increased blood pressure and counteracting the effects of lisinopril.
Clinical Implications
Given the significant interaction between ibuprofen and lisinopril, it is crucial for patients and healthcare providers to be aware of this potential issue. The study suggests that alternative pain relievers, such as acetaminophen, may be safer options for patients on antihypertensive therapy, as acetaminophen did not significantly affect blood pressure in the same study.
Conclusion
In summary, taking ibuprofen with lisinopril can lead to a significant increase in blood pressure, reducing the effectiveness of the antihypertensive treatment. Patients on lisinopril should consider alternative pain relievers and consult their healthcare provider to manage their medications safely.
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