Searched over 200M research papers for "Cancer insuline"
10 papers analyzed
These studies suggest that insulin and IGF-1 play significant roles in cancer cell proliferation and therapy, with strategies involving their regulation potentially improving cancer outcomes and treatment efficacy.
20 papers analyzed
The relationship between insulin and cancer has garnered significant attention due to the rising prevalence of obesity and type 2 diabetes, both of which are associated with hyperinsulinemia. Insulin and insulin-like growth factors (IGFs) are known to play crucial roles in cellular growth and metabolism, and their dysregulation has been implicated in cancer development and progression.
Insulin and IGF as Growth Factors in Cancer:
Hyperinsulinemia and Cancer Risk:
Insulin Receptor (IR) in Cancer:
Impact of Insulin on Cancer Therapy:
Insulin Treatment in Cancer Cachexia:
Dietary and Lifestyle Factors:
Prognostic Value of Insulin Levels:
The interplay between insulin, IGFs, and cancer is complex and multifaceted. Hyperinsulinemia and insulin resistance are significant risk factors for cancer development and progression. Overexpression of insulin receptors in cancer cells and the resulting autocrine loops contribute to tumor growth and therapy resistance. Targeting both IR and IGF-IR, along with managing insulin resistance through lifestyle and dietary interventions, holds promise for improving cancer outcomes. High fasting insulin levels serve as a prognostic marker in certain cancers, underscoring the need for tailored treatment strategies.
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