Cannabis cream
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Therapeutic Potential and Applications of Cannabis Cream
Cannabis Cream for Psoriasis Treatment
Efficacy of THC and CBD in Psoriasis
Recent studies have explored the therapeutic benefits of cannabis-enriched topical creams, particularly those containing delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), for treating psoriasis. A crossover, randomized, single-blinded study involving 20 volunteers demonstrated that a cannabis cream with THC:CBD significantly reduced the Psoriasis Area and Severity Index (PASI) score after four weeks of treatment1. Additionally, a combination of THC:CBD with a polyherbal formulation was found to be even more effective in reducing disease severity and improving the quality of life for patients, without significant adverse reactions or changes in blood profiles1.
Cannabis Cream for Acne and Sebum Reduction
Impact on Sebum and Erythema
Cannabis seeds extract cream has also shown promise in dermatological applications beyond psoriasis. A study investigating the efficacy of a 3% cannabis seeds extract cream on human cheek skin revealed significant reductions in sebum and erythema content over a 12-week period2. Healthy male participants applied the cream twice daily, and measurements taken at regular intervals indicated that the cannabis seeds extract was both safe and effective in reducing skin sebum and erythema, suggesting its potential use in treating acne vulgaris, seborrhea, papules, and pustules2.
Analytical Methods for Cannabinoid Determination
Quality Control in Cannabis-Based Products
For the development and quality control of cannabis-based preparations, accurate analytical methods are crucial. A study developed and validated a high-performance liquid chromatography (HPLC) method with photodiode array detection for determining CBD and THC in Cannabis sativa oil extract and infused ice cream3. This method proved to be simple, rapid, and effective, ensuring the stability and accurate quantification of cannabinoids, which is essential for maintaining the quality and efficacy of cannabis-based products3.
Cannabinoids in Dermatology
Broader Dermatological Applications
Cannabinoids have been investigated for various dermatological conditions, including pruritus, inflammatory skin diseases, and skin cancer. Notably, cannabinoids have shown significant potential in treating itch. In a study involving patients with uremic pruritus on maintenance hemodialysis, a cream containing structured physiologic lipids and endogenous cannabinoids eliminated pruritus in 38% of patients4. Another study found that an emollient cream with palmitoylethanolamide (PEA), which activates cannabinoid 1 (CB1) receptors, reduced itch by 86.4% in patients with prurigo, lichen simplex, and pruritus4. These findings highlight the potential of cannabinoids in managing various dermatological conditions effectively.
Conclusion
Cannabis creams, particularly those containing THC and CBD, have shown significant promise in treating psoriasis, reducing sebum and erythema, and managing pruritus. The development of reliable analytical methods for cannabinoid determination further supports the quality control of these products. As research continues, the therapeutic applications of cannabis in dermatology are likely to expand, offering new avenues for treatment and patient care.
Sources and full results
Most relevant research papers on this topic
Therapeutic Potential of Topical Cannabis for the Treatment of Psoriasis: A Preliminary Clinical Evaluation of Two Different Formulations
Topical cannabis creams containing THC:CBD alone or combined with a polyherbal formulation are safe and effective for treating psoriasis, with the combined formulation showing greater potential.
RCTThe safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content.
Base plus 3% Cannabis seeds extract cream is safe and effectively reduces skin sebum and erythema content, potentially improving facial appearance and treating acne vulgaris, seborrhea, papules and pustules.
RCTDetermination of cannabinoids in Cannabis sativa oil and infused ice cream by LC-DAD method.
The developed LC-DAD method is a simple and fast method for determining CBD and THC in Cannabis sativa oil extract and infused ice cream, useful for quality control purposes.
The role of cannabinoids in dermatology.
Cannabinoids show promise in treating itch in dermatologic conditions, with potential applications in treating pruritus, inflammatory skin diseases, and skin cancer.
Non-RCT
Rigorous JournalA Survey of Topical Cannabis Use in Canada
Canadians use topical cannabis for a wide range of systemic and dermatologic purposes, with limited evidence supporting its therapeutic efficacy and safety.
Observational StudyCannabis and Pain: A Clinical Review
Cannabis pharmacotherapy for pain shows modest evidence of effectiveness, but more research is needed to address potential side effects and risks.
Systematic Review
Highly CitedCannabis and the skin.
Cannabis shows potential in regulating pain, pruritus, and inflammation, making it a potential therapeutic agent for various dermatologic conditions.
Literature ReviewCannabis Therapeutic Applications - Review
Cannabis sativa shows promising therapeutic applications in treating epilepsy, multiple sclerosis, and cancer symptoms, with its potential anti-tumor activity gaining scientific interest.
Systematic ReviewChemical constituents of marijuana: the complex mixture of natural cannabinoids.
Cannabis contains a complex mixture of natural cannabinoids, which are responsible for its psychological properties and social aspects, making its approval as a medicine challenging.
Highly CitedThe Pharmacologic and Clinical Effects of Medical Cannabis
Medical cannabis significantly improves pain and muscle spasticity, with potential safety concerns including increased risk of schizophrenia, memory impairments, and accidental ingestions.
Highly Cited