Cbd dosage for sleep
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Summary
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Some studies suggest that CBD can improve sleep quality and reduce insomnia severity, while other studies indicate that its effects may not exceed those of melatonin or may reduce total sleep time and REM sleep in certain doses.
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CBD Dosage for Sleep: A Comprehensive Review
Introduction to CBD and Sleep
Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, has garnered attention for its potential therapeutic effects, including its impact on sleep. This article synthesizes findings from multiple studies to provide insights into the optimal CBD dosage for improving sleep quality.
Effects of CBD on Sleep-Wake Cycle
Animal Studies on CBD Dosage
Research on rats has shown that CBD can influence the sleep-wake cycle. In one study, different doses of CBD (2.5 mg/kg, 10 mg/kg, and 40 mg/kg) were administered to rats. The results indicated that higher doses (10 mg/kg and 40 mg/kg) significantly increased total sleep time during the light period, with 40 mg/kg also increasing slow-wave sleep (SWS) time, although this result was not statistically significant. Another study found that a single dose of 20 mg/kg CBD decreased SWS latency, while 40 mg/kg increased SWS time and decreased wakefulness.
Human Studies on CBD Dosage
Low to Moderate Doses
A study involving 1,793 adults with sleep disturbances compared the effects of 15 mg CBD, 5 mg melatonin, and combinations of these with minor cannabinoids. All formulations, including the 15 mg CBD isolate, significantly improved sleep quality, with no significant differences between the formulations . Another study with healthy college-aged individuals found that 50 mg of CBD daily for eight weeks improved sleep quality without affecting sleep quantity or mental health measures.
High Doses
In a study examining the effects of a single 200 mg dose of CBD combined with 10 mg THC on insomnia, the combination significantly decreased total sleep time and REM sleep, while increasing REM sleep latency. However, no next-day cognitive impairments were observed . Another study with 300 mg of CBD in healthy subjects found no significant effects on the sleep-wake cycle, suggesting that this dose does not alter normal sleep architecture.
Chronic Use and Safety
Chronic use of low doses of CBD (15 mg) has been shown to be safe and effective in improving sleep quality, with no severe side effects reported. The addition of minor cannabinoids like cannabinol (CBN) and cannabichromene (CBC) did not enhance the effects of CBD alone .
Conclusion
The optimal CBD dosage for sleep appears to vary depending on the individual and the specific sleep issues being addressed. Low to moderate doses (15-50 mg) have shown promise in improving sleep quality without significant side effects. Higher doses (200-300 mg) may have different effects, such as reducing total sleep time and altering REM sleep, but do not seem to impair next-day cognitive function. Further research is needed to explore the long-term effects and optimal dosages for different populations.
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