Cbd for pets
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Cannabidiol (CBD) for Pets: Current Research and Insights
Introduction to CBD Use in Pets
Cannabidiol (CBD), a non-psychotropic compound derived from Cannabis sativa L., has garnered significant interest for its potential therapeutic benefits in companion animals, particularly dogs and cats. This article synthesizes recent research on the efficacy, safety, and pharmacokinetics of CBD in pets, focusing on its use for managing anxiety, pain, inflammation, and other health conditions.
CBD for Anxiety and Stress in Pets
Anxiety Management in Dogs
CBD has shown promise in alleviating anxiety in dogs, particularly in stressful situations such as separation and car travel. A study demonstrated that a single dose of THC-free CBD distillate significantly reduced stress-related measures, including serum cortisol levels, heart rate, and anxious behaviors during these events10. However, more research is needed to fully understand the anxiolytic effects of CBD in dogs.
Limited Data on Cats
While there is substantial evidence supporting the use of CBD for anxiety in dogs, there is a significant gap in the literature regarding its effects on cats. Current studies have not provided sufficient data to conclude the efficacy of CBD for anxiety management in felines1.
Pain and Inflammation Management
Osteoarthritis and Chronic Pain in Dogs
Several studies have highlighted the potential of CBD in managing chronic pain, particularly osteoarthritic pain in dogs. Research indicates that CBD supplementation can significantly reduce pain and improve activity levels in dogs with osteoarthritis1 2 7. These findings suggest that CBD could be a valuable adjunctive therapy for managing chronic pain in canines.
Inflammation and Other Conditions
CBD's anti-inflammatory properties have also been explored, with some studies suggesting benefits in conditions such as pruritus and skin lesions3. However, the evidence is still preliminary, and further research is required to establish the therapeutic efficacy of CBD for these conditions.
Pharmacokinetics and Safety of CBD in Pets
Pharmacokinetics in Dogs and Cats
The pharmacokinetics of CBD differ between dogs and cats, with studies showing that cats have lower oral absorption and faster elimination rates compared to dogs5. This suggests that dosing regimens may need to be species-specific to achieve optimal therapeutic effects.
Safety Profile
CBD appears to be well-tolerated in dogs, with most studies reporting mild or unremarkable side effects2 6 8. Long-term studies have shown that daily CBD supplementation is generally safe, although some dogs may experience transient elevations in liver enzymes such as alkaline phosphatase (ALP)6 8. In cats, however, there is less data on long-term safety, and some adverse effects like excessive licking and head shaking have been observed5.
Pet Owners' Attitudes and Experiences
A survey of Slovenian pet owners revealed that a significant proportion (38.5%) had used CBD to treat their pets, with positive attitudes and personal experiences being significant predictors of CBD use4. This underscores the growing acceptance and demand for CBD as a therapeutic option among pet owners.
Conclusion
The current body of research suggests that CBD holds promise for managing anxiety, pain, and inflammation in pets, particularly dogs. However, there is a need for more systematic, randomized, and controlled trials to validate these findings and establish safe and effective dosing regimens. Additionally, more research is required to understand the pharmacokinetics and long-term safety of CBD in cats. As the popularity of CBD products for pets continues to rise, it is crucial for veterinarians to stay informed and guide pet owners based on the latest scientific evidence.
Sources and full results
Most relevant research papers on this topic
Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation.
CBD supplementation may reduce chronic osteoarthritic pain in dogs, but more research is needed to confirm its safety and efficacy in cats.
Systematic ReviewPharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge
Cannabidiol (CBD) shows some evidence of benefit in treating osteoarthritic pain in dogs, but more research is needed to confirm its efficacy and safety for other conditions.
Literature ReviewScientific Validation of Cannabidiol for Management of Dog and Cat Diseases.
CBD shows potential in improving clinical signs associated with osteoarthritis, pruritus, and epilepsy in dogs, but further studies are needed to confirm its therapeutic action and reduce anxiety and aggression.
Slovenian Pet Owners' Experience, Attitudes, and Predictors Regarding Cannabinoid Use in Dogs and Cats
Slovenian pet owners' decision to use CBDs for medicinal purposes is influenced by positive attitudes and personal experience, while postmodern health values have no significant impact.
Observational StudySingle-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats
CBD-rich hemp nutraceuticals are safe for healthy adult dogs, but cats show lower absorption and more adverse effects during oil administration.
Non-RCT
Animal Study
Rigorous Journal
Highly CitedLong-term daily feeding of cannabidiol is well-tolerated by healthy dogs
A once-daily oral dose of 4 mg CBD/kg BW is well-tolerated in clinically healthy dogs for a duration of 6-months, with no adverse effects on health and wellbeing.
RCTAnimal StudyUse of cannabis in the treatment of animals: a systematic review of randomized clinical trials
CBD shows some evidence in dogs with osteoarthritis to reduce pain and increase activity, but limited evidence against epilepsy and behavioral problems.
Systematic ReviewTolerability of long‐term cannabidiol supplementation to healthy adult dogs
Long-term CBD supplementation at 5 mg/kg is better tolerated than 10 mg/kg, with both dosages increasing alkaline phosphatase activity, but monitoring liver function is recommended.
RCTAnimal StudyCannabinoid treats as adjunctive therapy for pets: gaps in our knowledge
CBD-infused pet treats show promise as a non-traditional therapeutic option for dogs, but their short-term and long-term effects on companion animals remain largely unknown.
Literature ReviewA single dose of cannabidiol (CBD) positively influences measures of stress in dogs during separation and car travel
A single dose of CBD-free distillate can significantly reduce canine stress during separation and car travel, with varying effects depending on the measure and test.
RCTAnimal Study