Chamomile appears to be efficacious and safe for improving sleep quality and generalized anxiety disorder, but little evidence exists to show its effect on anxiety and insomnia.

Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: A systematic review and meta‐analysis of randomized trials and quasi‐randomized trials

Long-term chamomile treatment is safe and significantly reduces moderate-to-severe GAD symptoms, but does not significantly reduce relapse rates.

Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial.

Chamomile, as a non-pharmacologic and safe method, can help reduce cancer complications and improve appetite and quality of life in cancer patients.

Effect of Chamomile on the Complications of Cancer: A Systematic Review

Topical chamomile oil significantly reduced the need for acetaminophen in patients with knee osteoarthritis and may show beneficial effects on physical function and stiffness without causing adverse events.

Efficacy and safety of topical Matricaria chamomilla L. (chamomile) oil for knee osteoarthritis: A randomized controlled clinical trial.

Chamomile tea has moderate antioxidant, antimicrobial, and antiplatelet properties, with potential health benefits, but human studies are limited and sedative properties are not proven.

A Review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)

Homeopathy-cultivated chamomile infusions and essential oil show no genotoxic effects and exhibit antiproliferative activity on the cell cycle of Allium cepa, promoting sustainable cultivation and safe use of this medicinal species.

Antiproliferative potential and phenolic compounds of infusions and essential oil of chamomile cultivated with homeopathy.

Chamomile has numerous pharmacological effects and traditional uses, but more toxicity tests are needed to confirm its safety and validate its medicinal properties.

Chamomile: A Review of Its Traditional Uses, Chemical Constituents, Pharmacological Activities and Quality Control Studies

Chamomile extract significantly improves sleep quality in elderly people, making it a safe and effective modality for promoting their sleep.

The effects of chamomile extract on sleep quality among elderly people: A clinical trial.

Chamomile has shown promising effects in treating various diseases of old age, making it a safe and clinically useful herbal agent for elderly health promotion.

Chamomile: A Herbal Agent for Treatment of Diseases of the Elderly

Chamomile extracts show heterogeneity in chemical composition and antioxidant effects, with some showing cytotoxic effects at high concentrations, suggesting herbal medicine is not always safe.

Comparative Analysis of Phenolic Composition of Six Commercially Available Chamomile (Matricaria chamomilla L.) Extracts: Potential Biological Implications

Chamomile supplementation significantly improves glycemic control, lipid profiles, and oxidative stress indicators in diabetes mellitus patients, potentially reducing complications.

Chamomile (Matricaria recutita L.) and diabetes mellitus, current knowledge and the way forward: A systematic review.

Chamomile can reduce the negative effects of synthetic food additives, such as monosodium glutamate and synthetic dyes, on liver and kidney functions.

Amerolative Influence of Chamomile (Matricaria recutita L.) on Synthetic Food Additive Induced Probable Toxicity in Male Albino Rats التأثير المخفف للبابونج علي السمية المحتملة للمضافات الغذائية الصناعية في ذکور الجرذان البيضاء

Chamomile shows potential as an anti-inflammatory, antioxidant, analgesic, and antimicrobial agent, with potential benefits in treating various conditions, including inflammation, cancer, and hypertension.

A Comprehensive Study of Therapeutic Applications of Chamomile

Chamomile tea consumption for short term improves glycemic control and antioxidant status in patients with type 2 diabetes mellitus.

Chamomile tea improves glycemic indices and antioxidants status in patients with type 2 diabetes mellitus.

Extracting chamomile and sage at 80°C yields the highest antioxidant activity and phenolic content, but their consumption should be limited due to potential toxicity.

Evaluation of Antioxidant Activity, Toxicity, and Phenolic Profile of Aqueous Extracts of Chamomile (Matricaria chamomilla L.) and Sage (Salvia officinalis L.) Prepared at Different Temperatures

Bisabololoxide A, a main constituent in German chamomile, induces apoptosis in rat thymocytes at concentrations of 30 M or more, but is generally considered safe when used conventionally.

Bisabololoxide A, one of the main constituents in German chamomile extract, induces apoptosis in rat thymocytes

Chamomile is a widely used medicinal plant for treating various ailments, with its main pharmacological effect being its essential oils, but environmental conditions and stresses can alter its active substances.

Chamomile: A Review

Chamomile tea contains a glucuronoxylan (SN-50R) with antinociceptive, sedative, and anxiolytic-like effects, potentially contributing to the calming effects of chamomile tea ingestion.

Chamomile tea: Source of a glucuronoxylan with antinociceptive, sedative and anxiolytic-like effects.

Chamomile has been used in traditional medicine for over 2,000 years, promoting human health and promoting the development of new therapeutic applications.

Chamomile: A herbal medicine of the past with bright future.

Chamomile essential oil and its major constituents inhibit the activities of major human drug metabolizing enzymes, potentially affecting drug interactions.

Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes.

Some studies suggest chamomile is safe and beneficial for sleep, anxiety, cancer complications, and elderly health, while other studies indicate the need for more toxicity tests and caution due to potential cytotoxic effects at high concentrations.