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These studies suggest that cholesterol, particularly elevated LDL and low HDL levels, is a significant risk factor for heart and blood vessel diseases.
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Cholesterol is a waxy, fat-like substance that circulates in the blood and is essential for building cells and producing hormones. It is a type of lipid, a broader category of fat-like substances. Cholesterol is produced by the liver and also obtained from dietary sources, particularly animal products such as meat, milk, and eggs. While necessary for normal bodily functions, excessive cholesterol can lead to health issues.
Cholesterol travels through the bloodstream in particles called lipoproteins. The two main types are low-density lipoproteins (LDL) and high-density lipoproteins (HDL). LDL is often referred to as "bad cholesterol" because high levels can lead to plaque buildup in arteries, increasing the risk of heart disease. Conversely, HDL is known as "good cholesterol" because it helps remove cholesterol from the bloodstream, reducing the risk of arterial blockages .
Elevated levels of cholesterol and other lipids in the blood are medically termed hyperlipidemia. When the lipid levels are imbalanced, the condition is known as dyslipidemia. Both conditions are significant risk factors for cardiovascular diseases, including heart attacks, strokes, and peripheral artery disease (PAD). Hypercholesterolemia specifically refers to very high levels of cholesterol in the blood, further increasing the risk of heart disease.
High levels of LDL cholesterol contribute to the formation of plaques in the arteries, a condition known as atherosclerosis. These plaques can grow over time, leading to narrowed or blocked arteries, which can result in heart attacks or strokes . Conversely, HDL cholesterol helps transport cholesterol from the arteries to the liver, where it can be processed and excreted, thus protecting against atherosclerosis.
In the United States, the National Cholesterol Education Program (NCEP) was established to raise public awareness about the dangers of high cholesterol and to promote lifestyle changes to reduce cholesterol levels. This program has led to a significant decline in average serum cholesterol levels, primarily due to reduced intake of saturated fats and cholesterol. Clinically, the focus is on identifying individuals at high risk for coronary heart disease (CHD) and implementing dietary modifications or cholesterol-lowering medications as needed.
Understanding cholesterol and its impact on health is crucial for preventing cardiovascular diseases. Medical terms like hyperlipidemia, dyslipidemia, and hypercholesterolemia describe various cholesterol-related conditions that require attention and management. Public health initiatives and clinical interventions play vital roles in reducing the risks associated with high cholesterol levels.
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