Citirizine 10mg
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Efficacy and Safety of Cetirizine 10mg in Treating Allergic Conditions
Introduction to Cetirizine 10mg
Cetirizine, a second-generation antihistamine, is widely used to treat various allergic conditions such as chronic urticaria, allergic rhinitis, and asthma. It is known for its minimal sedative effects and high efficacy in alleviating allergy symptoms.
Chronic Urticaria Treatment with Cetirizine 10mg
Cetirizine 10mg has shown significant effectiveness in treating chronic urticaria. Studies indicate that cetirizine, when combined with total glucosides of paeony capsule (TGPC), results in a higher total effective rate and a lower relapse rate compared to cetirizine alone1. Additionally, increasing the dose of cetirizine to 20mg daily can further improve symptom control in patients who do not respond adequately to the standard 10mg dose3. This dose-dependent efficacy is attributed to cetirizine's ability to inhibit histamine-induced wheal and flare reactions8.
Seasonal Allergic Rhinitis and Asthma Management
Cetirizine 10mg daily is also effective in managing symptoms of seasonal allergic rhinitis and concomitant asthma. Patients treated with cetirizine experience significant improvement in rhinitis and asthma symptoms compared to those receiving a placebo2. The treatment is well-tolerated, with a higher completion rate among cetirizine-treated patients2. In children, cetirizine 10mg has been shown to significantly reduce symptoms of seasonal allergic rhinitis, providing effective relief and improving quality of life9.
Pharmacokinetics and Pharmacodynamics in Children
In pediatric populations, cetirizine is rapidly absorbed and maintains stable serum concentrations with a half-life of approximately 7 hours. Both 5mg and 10mg doses effectively suppress histamine-induced wheal and flare reactions, with the 10mg dose providing more pronounced effects4. This makes cetirizine a reliable option for managing allergic symptoms in children.
Adverse Reactions and Tolerability
The most common adverse reaction associated with cetirizine is somnolence, although the incidence varies among studies5. Despite this, cetirizine is generally well-tolerated, with minimal reports of severe adverse effects. In clinical trials, mild sedation was occasionally reported, but no patients withdrew from treatment due to adverse events10.
Conclusion
Cetirizine 10mg is a highly effective and well-tolerated antihistamine for treating chronic urticaria, allergic rhinitis, and asthma. Its efficacy can be enhanced by increasing the dose in patients with inadequate response to the standard dose. With minimal sedative effects and a favorable safety profile, cetirizine remains a preferred choice for managing allergic conditions in both adults and children.
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Most relevant research papers on this topic
Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine
TGPC combined with citirizine effectively treats chronic urticaria, with a low relapse rate and no evident adverse reactions.
RCTCetirizine in patients with seasonal rhinitis and concomitant asthma: prospective, randomized, placebo-controlled trial.
Cetirizine 10 mg daily is a safe and effective treatment for relieving upper and lower respiratory tract symptoms in patients with seasonal allergic rhinitis and concomitant asthma.
RCT
Highly CitedIncreasing the dose of cetirizine may lead to better control of chronic idiopathic urticaria: an open study of 21 patients
Increasing the dose of cetirizine to 20 mg daily may lead to better control of chronic idiopathic urticaria symptoms in patients who responded poorly to 10 mg daily of the drug.
Non-RCTCetirizine: a pharmacokinetic and pharmacodynamic evaluation in children with seasonal allergic rhinitis.
Cetirizine, 5 mg and 10 mg, effectively suppresses seasonal allergic rhinitis symptoms in children, with stable serum concentrations and stable wheal-and-flare areas.
RCTHighly CitedPlacebo‐controlled assessment of somnolence effect of cetirizine: a meta‐analysis
Cetirizine 10 mg daily is associated with a higher somnolence rate compared to placebo in patients aged 6 years and older, but the exact somnolence rate varies widely among different studies.
Meta-AnalysisEvaluation of some quality parameters of five brands of Cetirizine hydrochloride tablets marketed in Abuja, Nigeria.
Cetirizine hydrochloride 10mg tablets marketed in Abuja, Nigeria, meet quality standards for hardness, friability, disintegration, and dissolution.
Treatment of chronic urticaria with cetirizine dihydrochloride a non‐sedating antihistamine
Cetirizine dihydrochloride, a non-sedating H1-antagonist, effectively treats chronic urticaria with minimal sedative or anticholinergic side effects.
RCTInhibiting effect of cetirizine on histamine-induced and 48/80-induced wheals and flares, experimental dermographism, and cold-induced urticaria.
Cetirizine effectively inhibits histamine-induced and 48/80-induced wheals and flares, experimental dermographism, and cold-induced urticaria, with minimal sedative effects.
Non-RCTHighly CitedOnce-Daily Cetirizine Effective in the Treatment of Seasonal Allergic Rhinitis in Children Aged 6 to 1 Years: A Randomized, Double-Blind, Placebo-Controlled Study
Once-daily cetirizine 10 mg effectively improves symptoms of seasonal allergic rhinitis in children aged 6-11 years, with no significant adverse reactions.
RCTCetirizine in Children with Chronic Allergic Rhinitis
Cetirizine 10mg daily significantly improves symptoms of perennial allergic rhinitis in children aged 2 to 14 years, with no reported adverse events and minimal mild sedation.
RCT