Infusion of donor feces is significantly more effective for treating recurrent Clostridium difficile infection than vancomycin alone or with bowel lavage.

Duodenal infusion of donor feces for recurrent Clostridium difficile.

This update of the ESCMID treatment guidance document for Clostridium difficile infection emphasizes antibiotic treatment, with faecal transplantation recommended for multiple recurrent cases and colonic lavage for severe cases.

European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection.

Oral vancomycin should become the first choice for antibiotic treatment for Clostridium difficile infection, with fidaxomicin as an alternative, and vancomycin combined with faecal microbiota transplantation remains the primary therapy for multiple recurrent cases.

Update of treatment algorithms for Clostridium difficile infection.

Newer treatment methods like narrow-spectrum antibiotics and monoclonal antibodies show promise in improving Clostridium difficile infection treatment.

Update on Treatment of Clostridioides difficile Infection.

SER-109 effectively reduces the risk of recurrent C. difficile infection compared to placebo, with a similar safety profile.

SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection.

Vancomycin is more effective than metronidazole for achieving symptomatic cure in patients with C. difficile-associated diarrhoea, while fidaxomicin is more effective than vancomycin for achieving symptomatic cure.

Antibiotic treatment for Clostridium difficile-associated diarrhoea in adults.

Inflammatory bowel disease patients with C difficile infection should be tested, treated with vancomycin, and considered for fecal microbiota transplantation.

Management of Clostridium difficile Infection in Inflammatory Bowel Disease: Expert Review from the Clinical Practice Updates Committee of the AGA Institute

Fecal microbiota transplantation (FMT) shows potential benefits in treating recurrent Clostridioides difficile infection in immunocompetent individuals, but more research is needed to confirm its safety and effectiveness.

Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile).

Nitazoxanide and teicoplanin show potential as alternatives to traditional treatment for Clostridium difficile infections, while prebiotic formulations for prevention and recurrent infection are not clinically warranted.

Alternative Therapies for Clostridium difficile Infections

Current treatment guidelines recommend vancomycin and fidaxomicin for Clostridioides difficile infection, with metronidazole for mild-to-moderate disease and bezlotoxumab for recurrent infections.

Treatment of Clostridioides (Clostridium) difficile infection

Intestinal microbiota transplantation (IMT) is highly effective in resolving recurrent Clostridium difficile infection and pseudomembranous colitis, with disease resolution in 92% of cases, but effectiveness varies by route, relationship to stool donor, and treatment before infusion.

Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection.

Fecal microbiota transplantation is a safe, inexpensive, and effective treatment for Clostridium difficile infection, with about 90% of patients cured.

Treating Clostridium difficile infection with fecal microbiota transplantation.

Effective prevention, diagnosis, and treatment of Clostridium difficile infection in adults require antibiotics and fecal microbiota transplantation for prevention, deterring infection, and reducing recurrence.

Guidelines for Clostridium difficile infection in adults

Metronidazole remains the first choice for treating Clostridium difficile infection, with vancomycin recommended for serious cases or multiple recurrences.

Treatment of Clostridium difficile infection.

New diagnostic techniques and treatments for Clostridioides difficile infection have improved diagnosis and treatment outcomes, with vancomycin and fecal microbiota transplantation being recommended for multiple recurrences.

Clostridioides difficile: diagnosis and treatments

Tolevamer and metronidazole are inferior to antibiotic treatment for Clostridium difficile infection, with tolevamer being less effective than metronidazole.

Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials.

Bio-K+, a probiotic formulation combining Lactobacillus acidophilus, L. casei, and L. rhamnosus strains, shows potential in reducing Clostridium difficile infections in healthcare settings when administered to patients receiving antibiotics.

Primary prevention of Clostridium difficile infections with a specific probiotic combining Lactobacillus acidophilus, L. casei, and L. rhamnosus strains: assessing the evidence.

Colonoscopic fecal microbiota transplantation (FMT) using donor stool or patient's own stool shows better cure rates and lowers adverse events compared to nasoenteric route administration.

Effect of Fecal Microbiota Transplantation on Recurrence in Multiply Recurrent Clostridium difficile Infection

Clostridium difficile infection is a potentially life-threatening bacterial infection, with recurrent infections common and treatment options limited.

Clostridium difficile infection

How is Clostridium difficile infection treated?

These studies suggest that Clostridium difficile infection is treated primarily with antibiotics like vancomycin and fidaxomicin, with fecal microbiota transplantation recommended for recurrent cases, and newer methods like narrow-spectrum antibiotics and monoclonal antibodies showing promise.