The Coombs test is not the only tool available to distinguish immune from nonimmune hemolytic disorders.

Beyond the Coombs test.

Coombs' test can aid in diagnosing IMHA in dogs and cats, but its sensitivity can be improved through monovalent reagents, increased dilutions, and testing at 4°C.

Coombs' testing and its diagnostic significance in dogs and cats.

A positive Coombs test is common in acute leukaemia patients, but its relationship with FAB morphologic subtype, immune abnormalities, or leukemia course remains unclear.

Positive Coombs test in acute leukaemia

The radiolabeled Coombs antiglobulin test effectively diagnoses and manages immune platelet disorders, revealing increased IgG levels on platelets in idiopathic thrombocytopenic purpura patients and a role for C3 in the pathogenesis.

Immune thrombocytopenia. Use of a Coombs antiglobulin test to detect IgG and C3 on platelets.

The pattern of Coombs' test reactivity in dogs with immune-mediated haemolytic anaemia differs significantly from those with concurrent/underlying diseases, making it crucial for diagnosis.

Pattern of Coombs' test reactivity has diagnostic significance in dogs with immune-mediated haemolytic anaemia.

A positive Coombs test in Hodgkin's disease patients suggests active and advanced disease, with IgG anti-It potentially representing a unique antibody in Coombs-positive hemolytic anemia.

Positive Coombs test in Hodgkin's disease: significance and implications.

Positive Coombs test in 12.8% of SLE patients is associated with hemolytic anemia, anti-RNP, and anti-La antibodies.

Direct antiglobulin (Coombs) test in systemic lupus erythematosus patients

The Coombs test is a sensitive method for detecting incomplete antibodies, but optimal conditions are needed for maximum sensitivity.

Factors Affecting the Speed of Agglutination in the Coombs Test

The direct Coombs test is positive in lead poisoning cases, with a layer phenomenon in dogs' blood and potential correlation with cell immaturity or chemical trauma to the membrane.

The direct Coombs test in lead poisoning.

The Coombs antiglobulin test can detect reticulocytes, suggesting a non-immunologic mechanism for its development in certain conditions.

The Direct Coombs Test and Reticulocytes *

Anti-A and anti-B antibodies produced by immunization with various blood group substances and heterospecific pregnancy show two groups, indicating no proper distinction between "natural" or immune antibodies.

The behavior in the Coombs test of anti-A and anti-B produced by immunization with various blood group A and B substances and by heterospecific pregnancy.

Cephalothin may cause hemolytic anemia in patients with rheumatic heart disease, but the mechanism of action remains unclear.

Positive direct Coombs tests due to cephalothin.

The Coombs' test is a useful tool in veterinary medicine for diagnosing immune-mediated hemolytic anemia, but its sensitivity in both human and veterinary medicine has led to the development of more sensitive technologies.

The Coombs' test in veterinary medicine: past, present, future.

The U of MN Coombs' test is more sensitive for detecting immune-mediated hemolytic anemia in dogs when used in a microtiter-plate format, with multiple antisera dilutions increasing sensitivity, but monovalent antisera not increasing sensitivity.

Performance of 2 microtiter canine Coombs' tests.

The Coombs test is essential for diagnosing anemia etiology and determining compatibility for red blood cell transfusions.

Rediscovering the Coombs test

Cats with immune-mediated haemolytic anaemia are more likely to have persistent cold autoagglutination and positive Coombs' testing, but positive results may occur in other forms of anaemia.

Coombs', haemoplasma and retrovirus testing in feline anaemia.

A positive direct Coombs' test in the absence of hemolytic anemia predicts high disease activity and poor renal response in systemic lupus erythematosus patients, making it a useful biomarker for assessing disease activity and therapeutic response.

A positive direct Coombs’ test in the absence of hemolytic anemia predicts high disease activity and poor renal response in systemic lupus erythematosus

The Coombs test is a clinical tool used to measure hemolytic anemia or transfusion reactions, aiding oncology nurses in understanding the test's purpose and potential diagnoses.

The Coombs test.

Quinine and acetophenetidin (phenacetin) in a patient with hemolytic anemia, suggesting a potential link between drug-induced anemia and autoimmune states.

Drug-dependent Coombs (antiglobulin) test and anemia; observations on quinine and acetophenetidin (phenacetin).

These studies suggest the Coombs test is useful for diagnosing various immune-related conditions, including IMHA in pets, acute leukemia, idiopathic thrombocytopenic purpura, Hodgkin's disease, SLE, and lead poisoning, but it is not the only tool available and its sensitivity can be improved under specific conditions.