10 papers analyzed
These studies suggest the Coombs test is useful for diagnosing immune-mediated hemolytic anemia and other immune disorders in both humans and animals, but its sensitivity can be improved and it is not the only diagnostic tool available.
The Coombs test, also known as the antiglobulin test, is a diagnostic tool used to detect antibodies or complement proteins bound to the surface of red blood cells (RBCs). It is widely used in both human and veterinary medicine to diagnose conditions such as immune-mediated hemolytic anemia (IMHA) and other immune-related disorders.
Diagnostic Utility in Hemolytic Anemia:
Positive Coombs Test in Various Conditions:
Factors Affecting Test Sensitivity:
Application in Immune Thrombocytopenia:
The Coombs test is a valuable diagnostic tool for identifying immune-related hemolytic disorders and other conditions such as leukemia, Hodgkin's disease, and lead poisoning. Its sensitivity can be enhanced through various techniques, although false results are possible. The test's application extends beyond RBCs to platelets, demonstrating its versatility in diagnosing immune-mediated conditions.
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