cresents in membranous nephropathy

Introduction

Membranous nephropathy (MN) is a glomerular disease characterized by the thickening of the glomerular basement membrane due to immune complex deposition. This condition can lead to nephrotic syndrome and, in severe cases, progress to renal failure. Recent research has explored various aspects of MN, including its pathophysiology, treatment options, and unusual variants such as those involving crescent formation.

Key Insights

Crocin's Therapeutic Effects in MN:
- Crocin, a compound isolated from saffron and gardenia, has been shown to alleviate MN by reducing oxidative stress, podocyte loss, and immune injury. This is achieved through the activation of the Sirt1/Nrf2/HO-1 signaling pathways.
Unusual Variant with Crescent Formation:
- There exists a variant of MN characterized by abundant crescent formation and capsular synechiae, which can recur post-transplantation. This variant does not involve anti-glomerular basement membrane (anti-GBM) antibodies, suggesting a different underlying mechanism.

Conclusion

Research on membranous nephropathy highlights the potential of crocin as a therapeutic agent due to its ability to mitigate oxidative stress and immune injury. Additionally, an unusual variant of MN with crescent formation has been identified, which can recur after kidney transplantation and is not associated with anti-GBM antibodies. These findings underscore the complexity of MN and the need for tailored therapeutic approaches.

Cresents in membranous nephropathy

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Crocin improves the renal autophagy in rat experimental membranous nephropathy via regulating the SIRT1/Nrf2/HO-1 signaling pathway

Crocin alleviates membranous nephropathy by inhibiting immune injury and podocyte damage through activating the Sirt1/Nrf2/HO-1 pathways.

An unusual variant of membranous nephropathy with abundant crescent formation and recurrence in the transplanted kidney.

A rare form of membranous nephropathy with crescent formation, unrelated to anti-GBM antibody, can recur after kidney transplantation.

Recurrent membranous nephropathy in an allograft caused by IgG3κ targeting the PLA2 receptor.

Circulating monoclonal anti-PLA2R IgG3 caused recurrent membranous nephropathy in a kidney transplant patient, activating complement through the classic pathway.

Membranous nephropathy.

Membranous nephropathy is a glomerular disease with variable course and treatment options, with alternating corticosteroids and cytotoxic agents showing promising results.

Membranous nephropathy

Membranous nephropathy is a common cause of nephrotic syndrome in adults, with a difficult prognosis and relapses, but immunosuppressive therapy can reduce kidney replacement therapy and improve long-term renal prognosis.

Murine Membranous Nephropathy: Immunization with α3(IV) Collagen Fragment Induces Subepithelial Immune Complexes and FcγR-Independent Nephrotic Syndrome

This study establishes an active mouse model of murine membranen nephropathy, providing valuable insights into the pathogenesis and potential efficacy of novel experimental therapies.

Progression of membranous nephropathy to acute crescentic rapidly progressive glomerulonephritis and response to pulse methylprednisolone.

Pulse methylprednisolone effectively improves renal function in patients with membranous nephropathy evolving into acute crescentic rapidly progressive glomerulonephritis.

Idiopathic membranous nephropathy: definition and relevance of a partial remission.

A partial remission in nephrotic membranous nephropathy patients is important, as it predicts slower progression and better renal survival.

Glomerular diseases: membranous nephropathy--a modern view.

Idiopathic membranous nephropathy is a treatable disease in many patients, with cyclical therapy, glucocorticoids, and cytotoxic agents preserving renal function and reducing relapses.

A randomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy.

A 6-month regimen of cyclophosphamide and steroids effectively induces remissions, arrests renal insufficiency progression, and improves quality of life in adults with nephrotic syndrome caused by idiopathic membranous nephropathy.

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