10 papers analyzed
These studies suggest that depression is moderately heritable, with genetic factors such as serotonin transporter polymorphisms, neurotrophic processes, and mitochondrial DNA playing roles, while gene-environment interactions and family environment also contribute. Future research should focus on identifying specific genetic markers, understanding gene-environment interactions, and exploring the role of energy metabolism in depression.
Depression has a significant genetic component, with heritability estimates suggesting that up to 50% of the risk for developing major depressive disorder (MDD) can be attributed to genetic factors . Studies have shown that depressive disorders are more common in the relatives of depressed individuals, indicating a familial aggregation that is at least partly due to genetic factors . Additionally, specific genetic polymorphisms, such as those in the serotonin transporter promoter region (5-HTTLPR), have been associated with depression-related traits, although their direct link to MDD remains inconclusive .
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