Is DMAA (1,3-dimethylamylamine) safe?

Introduction

DMAA (1,3-dimethylamylamine) is a compound that has been used in dietary supplements and is known for its stimulant effects. However, its safety has been questioned due to reports of adverse effects and its regulatory status.

Key Insights from Research Papers

DMAA has been associated with cerebral hemorrhage in adults, indicating potential severe adverse effects on the brain.
Doubts exist about the natural occurrence of DMAA in supplements, with research suggesting that the DMAA found in supplements is likely synthetic and not derived from geranium species as some claims suggest .
Reports of adverse clinical effects such as tachycardia, nausea, and vomiting have been linked to DMAA-containing products, although these effects may also be due to other ingredients in the products.
DMAA has shown potential for abuse, with effects similar to cocaine and methamphetamine in animal studies, suggesting a high risk of misuse and dependency.
Cardiac arrest and other serious cardiovascular events have been reported following the ingestion of DMAA-containing supplements, highlighting the risk of life-threatening conditions .
Despite regulatory actions, DMAA continues to be found in dietary supplements, indicating ongoing concerns about its illegal presence and the challenges in controlling its distribution .

Conclusion

The research indicates that DMAA poses significant health risks, including cerebral hemorrhage, cardiovascular events, and potential for abuse. The substance is often synthetically added to supplements and its presence in such products is illegal and unsafe. The continued detection of DMAA in supplements despite regulatory bans underscores the importance of monitoring and enforcement to protect public health.

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Is DMAA (1,3-dimethylamylamine) safe?

Summary

Consensus Meter

Introduction

Key Insights from Research Papers

Conclusion

Sources and full results

Use of recreational drug 1,3 Dimethylamylamine (DMAA) [corrected] associated with cerebral hemorrhage.

DMAA use as a recreational stimulant drug is associated with three cases of cerebral hemorrhage in adults, highlighting the need for caution in its use.

Could 1,3 dimethylamylamine (DMAA) in food supplements have a natural origin?

The amount of synthetic DMAA found in sports supplements is likely added, as it is unlikely to be sourced from nature and can cause severe adverse physiological effects.

Exposures to 1,3-dimethylamylamine-containing products reported to Texas poison centers

DMAA-containing products, such as OxyElite ProTM, are generally not serious and often cause tachycardia, nausea, and vomiting, with common treatments being dilution, food, and activated charcoal.

Abuse liability of the dietary supplement dimethylamylamine.

DMAA has potential for abuse due to its cocaine- and methamphetamine-like effects and conditioned place preference, warranting further consideration of its control.

Cardiac arrest in a 21-year-old man after ingestion of 1,3-DMAA-containing workout supplement.

A young man suffered cardiac arrest after ingestion of a 1,3-DMAA-containing workout supplement, emphasizing the importance of maintaining a high index of suspicion in healthy individuals presenting with cardiac arrest.

1,3-Dimethylamylamine (DMAA) in supplements and geranium products: natural or synthetic?

DMAA in pre-workout supplements is synthetic and not found in commercial geranium extracts, indicating its safety and origin in supplements.

Rapid assessment of the illegal presence of 1,3-dimethylamylamine (DMAA) in sports nutrition and dietary supplements using 1H NMR spectroscopy.

The developed NMR spectroscopic method effectively detects and quantifies the illegal presence of 1,3-dimethylamylamine (DMAA) in sports nutrition and dietary supplements, making it suitable for routine use in food testing, customs, and doping control laboratories.

Pharmacokinetic and Toxicological Aspects of 1,3-Dimethylamylamine with Clinical and Forensic Relevance

1,3-DMAA is a widely used stimulant with potential health risks, and despite restrictions, it remains found in dietary supplements and doping controls.

Case reports: Death of active duty soldiers following ingestion of dietary supplements containing 1,3-dimethylamylamine (DMAA).

Dietary supplements containing 1,3-dimethylamylamine (DMAA) may be associated with significant adverse consequences in active duty soldiers, similar to those experienced with other sympathomimetic drugs.

"Plant or poison": A netnographic study of recreational use of 1,3-dimethylamylamine (DMAA).

Drug users show interest in recreational use of 1,3-dimethylamylamine (DMAA), but its low value for intoxication and potential for weight loss hinder further experimentation.

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