Does amlodipine cause depression

Pro Research Analysisby

Searched over 200M research papers

Analyzed relevant papers

Amlodipine and Its Potential Link to Depression

Introduction to Amlodipine

Amlodipine is a dihydropyridine calcium channel blocker primarily used to treat hypertension and chronic stable angina pectoris. It works by causing vasodilation, which helps to lower blood pressure and reduce the workload on the heart Ok2018Lehmann1993Deanfield1994+1 MORE.

Cardiovascular Effects of Amlodipine

Amlodipine is known for its effectiveness in reducing myocardial ischemia and angina episodes. Studies have shown that it significantly decreases the frequency of ST segment depression and increases exercise tolerance in patients with coronary artery disease Lehmann1993Deanfield1994Glasser1988. Additionally, it has been found to reduce both symptomatic and asymptomatic ischemic events over a 24-hour period .

Amlodipine Toxicity and Cardiac Depression

In cases of amlodipine toxicity, severe cardiovascular depression can occur. This is characterized by significant myocardial depression and vasodilation, which can be life-threatening. Treatment with lipid emulsion has been shown to alleviate these severe cardiovascular effects by acting as a lipid sink, helping to detoxify the drug .

Investigating the Link Between Amlodipine and Depression

While the cardiovascular effects of amlodipine are well-documented, there is limited direct evidence linking amlodipine to the onset of depression. The abstracts provided do not specifically address depression as a side effect of amlodipine. Instead, they focus on its cardiovascular impacts and efficacy in treating angina and hypertension Ok2018Lehmann1993Deanfield1994+1 MORE.

Conclusion

Based on the available research, there is no direct evidence to suggest that amlodipine causes depression. The studies primarily highlight its cardiovascular benefits and potential toxicity at high doses, but do not mention depression as a side effect. Further research would be needed to conclusively determine any potential link between amlodipine and depression.

Sources and full results

Most relevant research papers on this topic

Amlodipine toxicity and lipid emulsion

Lipid emulsion treatment can partially contribute to recovery from cardiovascular depression induced by toxic doses of amlodipine, especially when combined with supportive care.

Case ReportVery Rigorous Journal

2018·

4citations

·S. Ok et al.

Korean Journal of Anesthesiology·

DOI

Pharmacokinetics and additional anti-ischaemic effectiveness of amlodipine, a once-daily calcium antagonist, during acute and long-term therapy of stable angina pectoris in patients pre-treated with a beta-blocker.

Amlodipine 10 mg, a calcium antagonist, significantly reduces exercise-induced ST segment depression and increases ischaemia-free workload capacity in patients with stable angina pectoris.

RCT

1993·

20citations

·G. Lehmann et al.

European heart journal·

DOI

Amlodipine reduces transient myocardial ischemia in patients with coronary artery disease: double-blind Circadian Anti-Ischemia Program in Europe (CAPE Trial).

Once-daily amlodipine significantly reduces both symptomatic and asymptomatic ischemic events over 24 hours in patients with chronic stable angina.

RCTLarge Human Trial

1994·

118citations

·J. Deanfield et al.

Journal of the American College of Cardiology·

DOI

Clinical safety and efficacy of once-a-day amlodipine for chronic stable angina pectoris.

Once-a-day amlodipine is a safe and effective treatment for chronic stable angina pectoris, reducing angina episodes and improving exercise tolerance and ST-segment depression.

RCT

1988·

26citations

·Stephen P. Glasser et al.

The American journal of cardiology·

DOI

A Case of Life-threatening Amlodipine and Atenolol Overdose

A 66-year-old male with a history of depression developed cardiac arrest after consuming 25 tablets of amlodipine-atenolol, highlighting the importance of timely and aggressive management in such cases.

Case Report

2019·

14citations

·S. Tale et al.

Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·

DOI

Amlodipine in chronic stable angina: results of a multicenter double-blind crossover trial.

Amlodipine effectively increases exercise duration and reduces angina attacks, while maintaining symptom control in chronic stable angina patients.

RCT

1995·

44citations

·M. Ezekowitz et al.

American heart journal·

DOI

Severe Amlodipine Toxicity: A Case Rescued with Extracorporeal Membrane Oxygenation

A rare case of a massive amlodipine overdose (400 mg) was successfully managed with extracorporeal membrane oxygenation, resulting in successful patient discharge.

Case ReportRigorous Journal

2020·

16citations

·Anand Sutar et al.

Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·

DOI

Efficacy and safety of amlodipine in vasospastic angina: An interim report of a multicenter, placebo-controlled trial

Amlodipine is a well-tolerated and effective antiischemic and antianginal therapy for patients with chronic stable angina pectoris, reducing angina attacks and nitroglycerin consumption.

RCT

1989·

18citations

·R. Chahine et al.

American Heart Journal·

DOI

Randomized, double-blind crossover study to investigate the effects of amlodipine and isosorbide mononitrate on the time course and severity of exercise-induced myocardial stunning.

Amlodipine effectively reduces exercise-induced myocardial stunning compared to isosorbide mononitrate, potentially due to preventing calcium overload.

RCT

1998·

33citations

·C. A. Rinaldi et al.

Circulation·

DOI

Amlodipine overdose complicated by non-cardiogenic pulmonary edema and diffuse alveolar hemorrhage: A case report

Amlodipine overdose can lead to non-cardiogenic pulmonary edema and diffuse alveolar hemorrhage, requiring intensive care and supportive measures.

Case ReportRigorous Journal

2022·

7citations

·W. Bringgold et al.

Saudi Journal of Anaesthesia·

DOI

Try another search

how much protein

alcohol hallucinations

serious mental illness

hamilton depression rating scale

opiod addiction

anxiety screening