Does Creatine Impact Atrial Fibrillation?

Research Analysis by Consensus

Consensus Meter

Yes0%

Possibly0%

No0%

Introduction

Atrial fibrillation (AF) is a common cardiac arrhythmia that can lead to serious complications such as stroke and heart failure. The potential impact of creatine supplementation on atrial fibrillation is a topic of interest, particularly given the widespread use of creatine among athletes and individuals seeking to enhance physical performance.

Key Insights

Creatine and Atrial Fibrillation Incidence:
- There is a reported case of a young man developing atrial fibrillation potentially linked to creatine monohydrate supplementation, suggesting a possible association between creatine use and the onset of AF in individuals without structural heart disease.
Renal Function and Atrial Fibrillation:
- Reduced creatinine clearance (CrCl) is associated with an increased risk of adverse outcomes, including thromboembolism and all-cause death, in patients with non-valvular atrial fibrillation .
- Lower eGFR and higher urine albumin-to-creatinine ratios are significantly associated with a greater risk of incident atrial fibrillation, indicating that impaired kidney function may contribute to the development of AF.
Creatine Phosphate and Arrhythmias:
- Creatine phosphate has been shown to provide protection against reperfusion-induced arrhythmias in rat heart models, suggesting potential anti-arrhythmic properties.
Creatine Phosphokinase MB and Atrial Fibrillation:
- Elevated postoperative creatine phosphokinase MB levels were not found to predict long-term cardiac death or the development of atrial fibrillation after coronary artery bypass graft surgery.

Conclusion

The available research suggests a potential link between creatine supplementation and the onset of atrial fibrillation, particularly in individuals without pre-existing heart conditions. Additionally, impaired renal function is a significant risk factor for developing atrial fibrillation. While creatine phosphate may have protective effects against certain types of arrhythmias, elevated creatine phosphokinase MB levels do not appear to predict long-term AF outcomes. Further studies are needed to fully understand the mechanisms and implications of creatine use in relation to atrial fibrillation.

Research Analysis by Consensus

Consensus Meter

Introduction

Key Insights

Conclusion

Sources and full results

Lone Atrial Fibrillation Associated with Creatine Monohydrate Supplementation

eGFR and Albuminuria in Relation to Risk of Incident Atrial Fibrillation: A Meta-Analysis of the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Cardiovascular Health Study.

Impact of creatinine clearance on outcomes in patients with non-valvular atrial fibrillation: a subanalysis of the J-RHYTHM Registry

Creatine phosphate and protection against reperfusion-induced arrhythmias in the rat heart.

Does Creatine Phosphokinase MB Predict Long-Term Cardiac Death or Atrial Fibrillation?

Relation of Stroke and Major Bleeding to Creatinine Clearance in Patients With Atrial Fibrillation (from the Fushimi AF Registry).

Apixaban 5 mg Twice Daily and Clinical Outcomes in Patients With Atrial Fibrillation and Advanced Age, Low Body Weight, or High Creatinine: A Secondary Analysis of a Randomized Clinical Trial.

Randomized Trial of Carnitine for the Prevention of Perioperative Atrial Fibrillation.

Atrial contractile dysfunction after short-term atrial fibrillation is reduced by verapamil but increased by BAY K8644.

Atrial fibrillation in the setting of acute myocardial infarction: the GUSTO-I experience. Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries.

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