Does High carbohydrate intake cause irritable gut?

Introduction

The relationship between high carbohydrate intake and gut health, particularly in the context of irritable bowel syndrome (IBS) and other gastrointestinal issues, has been a subject of extensive research. This synthesis aims to consolidate findings from multiple studies to determine whether high carbohydrate intake causes irritable gut.

Key Insights

Gut Inflammation and Barrier Impairment:
- High carbohydrate diets can induce endoplasmic reticulum stress, oxidative stress, and promote inflammation and apoptosis in the gut, leading to impaired intestinal barriers .
- Increased gut permeability and endotoxemia are linked to high carbohydrate intake, which can result in inflammation due to decreased tight junction protein expression and butyric acid deficiency.
Microbiota Alterations:
- High carbohydrate diets are associated with altered gut microbiome diversity, including a decrease in beneficial bacteria and an increase in harmful bacteria like Enterobacteriaceae, which can contribute to gut inflammation and impaired glucose homeostasis .
- Changes in gut microbiota due to high carbohydrate intake can lead to increased gut permeability and inflammation, further exacerbating gut health issues .
Irritable Bowel Syndrome (IBS) Symptoms:
- Poorly digested, fermentable carbohydrates can induce IBS symptoms such as postprandial discomfort, bloating, and abdominal pain, primarily due to colonic hypersensitivity to distension rather than excessive gas production .
- High carbohydrate intake, particularly from poorly absorbable carbohydrates, can lead to abnormal accumulation of intestinal fluid and increased symptoms in IBS patients .
Gut Health in Non-Mammals:
- Studies on fish have shown that high carbohydrate diets can lead to gut inflammation, reduced antioxidant capacity, and impaired gut barrier function, suggesting similar mechanisms may be at play in humans .

Conclusion

High carbohydrate intake is associated with several adverse effects on gut health, including increased gut permeability, inflammation, and altered gut microbiota. These changes can exacerbate symptoms of irritable bowel syndrome and other gastrointestinal issues. The evidence suggests that managing carbohydrate intake and focusing on gut microbiota health may be crucial for mitigating these effects.

Does High carbohydrate intake cause irritable gut?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

High carbohydrate diet induced endoplasmic reticulum stress and oxidative stress, promoted inflammation and apoptosis, impaired intestinal barrier of juvenile largemouth bass (Micropterus salmoides).

High carbohydrate diets in juvenile largemouth bass cause endoplasmic reticulum stress and oxidative stress, leading to intestinal inflammation and apoptosis.

Effects of High Carbohydrate Diet-Modulated Microbiota on Gut Health in Chinese Perch

High-carbohydrate diets in Chinese perch cause gut damage due to changes in gut microbial metabolism, with mycoplasma and butyric acid-producing bacteria playing a key role.

Interaction effect between NAFLD severity and high carbohydrate diet on gut microbiome alteration and hepatic de novo lipogenesis

A high carbohydrate diet is associated with altered gut microbiome, impaired glucose homeostasis, and upregulation of hepatic de novo lipogenesis, contributing to the development of nonalcoholic fatty liver disease.

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation.

A high-fat diet alters gut microbiota, leading to inflammation and the development of hyperphagia and obesity in rats.

Abnormal accumulation of intestinal fluid following ingestion of an unabsorbable carbohydrate in patients with irritable bowel syndrome: an MRI study

IBS patients experience abnormal intestinal fluid accumulation after ingestion of unabsorbable carbohydrates, compared to healthy controls.

Dietary Carbohydrate Constituents Related to Gut Dysbiosis and Health

High-carbohydrate intake is associated with imbalanced gut microbiota and host health, with specific types of carbohydrates influencing both factors.

Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.

Colon hypersensitivity to distension, rather than excessive gas production, produces carbohydrate-related symptoms in patients with irritable bowel syndrome.

Short-Term Very High Carbohydrate Diet and Gut-Training Have Minor Effects on Gastrointestinal Status and Performance in Highly Trained Endurance Athletes

Short-term very high carbohydrate diet and gut-training have minor effects on gastrointestinal status and performance in highly trained endurance athletes, suggesting that meeting minimum carbohydrate guidelines is crucial for optimal performance.

Dietary fibre and the gut microbiota

Dietary fiber and resistant carbohydrates significantly influence the composition and metabolism of gut microbiota, impacting gut health and affecting colonic pH.

Fermentable carbohydrate restriction reduces luminal bifidobacteria and gastrointestinal symptoms in patients with irritable bowel syndrome.

Fermentable carbohydrate restriction effectively reduces luminal bifidobacteria concentration and proportion in patients with irritable bowel syndrome, improving gastrointestinal symptoms.

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