Does lisinopril raise blood sugar
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Summary
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These studies suggest lisinopril does not raise blood sugar and may improve insulin sensitivity and lower blood glucose levels.
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Does Lisinopril Raise Blood Sugar?
Lisinopril and Blood Sugar Levels
Lisinopril, an ACE inhibitor, is commonly prescribed for managing hypertension and certain heart conditions. Concerns about its impact on blood sugar levels are important, especially for patients with diabetes or those at risk of developing diabetes.
Lisinopril and Insulin Sensitivity
Several studies have investigated the effects of lisinopril on insulin sensitivity and blood glucose levels. Research indicates that lisinopril may actually improve insulin sensitivity rather than raise blood sugar levels. In a study comparing lisinopril and losartan, lisinopril significantly increased glucose infusion rate (GIR) and total glucose requirement (TGR), suggesting an improvement in insulin sensitivity. Another study found that lisinopril administration significantly improved whole-body glucose disposal and non-oxidative glucose metabolism in elderly hypertensive patients.
Lisinopril in Diabetic Patients
In patients with type 2 diabetes, lisinopril has been shown to be effective in reducing blood pressure and urinary albumin excretion, which are critical factors in managing diabetes-related complications. The CALM study demonstrated that lisinopril significantly reduced diastolic blood pressure and urinary albumin:creatinine ratio, indicating its beneficial effects in diabetic patients.
Animal Studies on Lisinopril and Blood Glucose
Animal studies have also explored the impact of lisinopril on blood glucose levels. One study aimed to evaluate the effect of lisinopril on blood glucose levels in alloxan-induced diabetic rats. The findings suggested that lisinopril, when given alone or in combination with oral anti-diabetic drugs, did not raise blood glucose levels.
Conclusion
Current research suggests that lisinopril does not raise blood sugar levels. Instead, it appears to improve insulin sensitivity and has beneficial effects on glucose metabolism, particularly in hypertensive and diabetic patients. These findings are consistent across human and animal studies, providing a comprehensive understanding of lisinopril's impact on blood glucose levels.
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