Does omeprazole have magnesium in it
Pro Research Analysisby 
Searched over 200M research papers
Does Omeprazole Contain Magnesium?
Omeprazole Formulation and Magnesium Content
Omeprazole, a widely used proton pump inhibitor (PPI), is available in various formulations, some of which include magnesium. Specifically, omeprazole magnesium is a common form used in enteric-coated tablets to enhance stability and absorption in the intestinal pH environment2 3. This formulation is designed to prevent degradation in the acidic environment of the stomach, ensuring the drug's efficacy10.
Omeprazole Magnesium and Its Properties
Omeprazole magnesium has been shown to possess fair flow and compressibility properties, making it suitable for tablet formulation2 3. Studies have confirmed that omeprazole magnesium complies with United States Pharmacopeia (USP) standards regarding fineness, flowability, and compressibility, which are critical for the drug's performance and stability2 3.
Clinical Implications of Magnesium in Omeprazole
The inclusion of magnesium in omeprazole formulations has clinical implications, particularly concerning magnesium levels in patients. Chronic use of PPIs, including omeprazole magnesium, has been associated with hypomagnesemia, a condition characterized by low magnesium levels in the blood1 6 9. This condition can lead to various health issues, including electrolyte imbalances and potential cardiac complications such as Torsade de Pointes1.
Monitoring Magnesium Levels in Patients
Given the risk of hypomagnesemia, it is crucial for healthcare providers to monitor magnesium levels in patients on long-term omeprazole therapy. Studies have highlighted that a significant percentage of patients on omeprazole do not have their magnesium levels regularly checked, which can lead to undiagnosed and untreated hypomagnesemia1. Therefore, regular monitoring and appropriate supplementation, if necessary, are recommended to mitigate these risks1 6.
Conclusion
In summary, omeprazole does contain magnesium in certain formulations, specifically in omeprazole magnesium enteric-coated tablets. While this formulation enhances the drug's stability and absorption, it also necessitates careful monitoring of magnesium levels in patients to prevent potential deficiencies and associated health risks. Regular assessment and appropriate management can help ensure the safe and effective use of omeprazole magnesium.
Sources and full results
Most relevant research papers on this topic
A retrospective analysis of any trends in magnesium level for patients on omeprazole 10 mg/5 ml oral suspension from January to June 2012 (inclusive) in response to the MHRA Drug Safety Update April 2012
Paediatric patients on omeprazole 10 mg/5 ml suspension may have hypomagnesaemia, but only 50% of patients had their magnesium levels measured, suggesting prescribers may not monitor these levels.
Observational Study
Very Rigorous JournalPreformulation Studies for Generic Omeprazole Magnesium Enteric Coated Tablets
Omeprazole magnesium enteric coated tablets meet USP standards for fineness, flowability, and compressibility, with no significant changes in concentration over a 30-day period.
Rigorous JournalPreformulation Studies for Generic Omeprazole Magnesium Enteric Coated Tablets: Advance Study
Omeprazole magnesium enteric coated tablets have fair flow and compressibility properties, complies with USP standards, and shows no significant changes in concentration over a 30-day period.
A Prospective, Placebo‐Controlled Pilot Evaluation of the Effect of Omeprazole on Serum Calcium, Magnesium, Cobalamin, Gastrin Concentrations, and Bone in Cats
Prolonged proton pump inhibitor treatment in cats leads to hypergastrinemia and abrupt withdrawal may result in rebound acid hypersecretion.
RCT
Animal StudyComparison of Prilosec OTCTM (omeprazole magnesium 20·6 mg) to placebo for 14 days in the treatment of frequent heartburn
Prilosec OTC (omeprazole magnesium 20-6 mg) is a safe and effective over-the-counter treatment for frequent heartburn when administered as a 14-day regimen.
RCTUltrastructural intestinal mucosa change after prolonged inhibition of gastric acid secretion by omeprazole in male rats
Prolonged omeprazole treatment in rats leads to small intestinal inflammation, villous atrophy, and decreased magnesium absorption, causing proton pump inhibitor-induced hypomagnesemia.
Non-RCTAnimal StudyLow gut microbiota diversity and dietary magnesium intake are associated with the development of PPI‐induced hypomagnesemia
Low gut microbiota diversity and dietary magnesium intake are associated with the development of proton pump inhibitor-induced hypomagnesemia, potentially posing a risk for malabsorption of magnesium in the colon.
Non-RCTAnimal StudyEsomeprazole magnesium.
Esomeprazole magnesium inhibits gastric acid production by binding to H+/K+ ATPase, preventing acid secretion and promoting acid neutralization.
Omeprazole suppressed plasma magnesium level and duodenal magnesium absorption in male Sprague-Dawley rats
Omeprazole causes systemic magnesium deficiency in rats, potentially due to increased secreted HCO3 in the duodenum affecting duodenal magnesium absorption.
Non-RCTAnimal Study