Doses of crestor
Pro Research Analysisby 
Searched over 200M research papers
Consensus Meter
Dosages of Crestor (Rosuvastatin)
Introduction to Crestor (Rosuvastatin)
Crestor, the brand name for rosuvastatin, is a statin medication primarily used to treat primary hypercholesterolemia and combined dyslipidemia when dietary changes alone are insufficient. It has been shown to have a favorable impact on lipid profiles compared to other statins, making it a popular choice for managing cholesterol levels .
Standard Dosages of Crestor
Initial and Maintenance Dosages
The usual starting dose of Crestor is 10 mg once daily. This dosage has been effective in reducing LDL cholesterol to below recommended target levels in nearly 80% of patients at risk, as demonstrated in phase III clinical trials . For patients requiring more significant cholesterol reduction, the dosage can be increased to 20 mg daily.
Maximum Dosage
In cases of severe familial hypercholesterolemia, the dosage may be increased up to a maximum of 40 mg daily. This higher dosage is reserved for patients who do not achieve their cholesterol targets with lower doses .
Bioequivalence Studies
Fixed-Dose Combinations
A bioequivalence study compared the pharmacokinetics of a fixed-dose combination of losartan, amlodipine, and rosuvastatin (Sanofi) with coadministered Lozap® AM (losartan + amlodipine) and Crestor® (rosuvastatin). The study involved two strengths of the fixed-dose combination: 50 mg + 5 mg + 10 mg and 100 mg + 5 mg + 20 mg. The results showed that the fixed-dose combinations were bioequivalent to the coadministered drugs in terms of pharmacokinetic parameters.
Conclusion
Crestor (rosuvastatin) is a highly effective statin for managing cholesterol levels, with standard dosages ranging from 10 mg to 40 mg daily depending on the severity of the condition. Bioequivalence studies have confirmed that fixed-dose combinations including rosuvastatin are as effective as the individual components, providing flexibility in treatment options .
Sources and full results
Most relevant research papers on this topic