Drinking with omeprazole
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Drinking Alcohol with Omeprazole: Risks and Considerations
Omeprazole and Alcohol-Induced Gastric Ulcers
Omeprazole (OME) is a widely used proton pump inhibitor (PPI) for treating gastric ulcers and other acid-related disorders. However, combining omeprazole with alcohol can have significant implications for gastric health. Research has shown that omeprazole, when used in conjunction with alcohol, can help mitigate some of the oxidative stress and inflammatory responses induced by alcohol consumption. In a study involving ethanol-induced gastric ulcers in rats, omeprazole, especially when combined with Patchouli Alcohol (PA), demonstrated significant gastroprotective effects by reducing ulcer areas and modulating oxidative stress and inflammatory factors1. This suggests that while omeprazole can offer some protective benefits against alcohol-induced gastric damage, it is not without its limitations and potential side effects.
Omeprazole and Vitamin B12 Absorption
Another critical consideration when drinking alcohol while on omeprazole is its impact on vitamin B12 absorption. Omeprazole-induced hypochlorhydria (reduced stomach acid) can significantly impair the absorption of protein-bound vitamin B12. A study found that elderly subjects treated with omeprazole had significantly lower absorption rates of protein-bound vitamin B12 compared to normal subjects. Interestingly, the ingestion of an acidic drink, such as cranberry juice, improved vitamin B12 absorption in these individuals2. This indicates that while omeprazole can impair nutrient absorption, certain dietary adjustments may help mitigate these effects.
Conclusion
In summary, while omeprazole can offer protective benefits against alcohol-induced gastric damage, it also poses risks such as impaired vitamin B12 absorption. Combining omeprazole with alcohol should be approached with caution, and individuals may need to consider dietary adjustments to counteract potential nutrient absorption issues. Always consult with a healthcare provider for personalized advice.
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Most relevant research papers on this topic
A potential drug combination of omeprazole and patchouli alcohol significantly normalizes oxidative stress and inflammatory responses against gastric ulcer in ethanol-induced rat model.
The combination of omeprazole and patchouli alcohol effectively reduces gastric ulcer areas, modulates oxidative stress, and reduces inflammatory responses in ethanol-induced rat models, potentially playing a crucial role in gastric mucosa protection.
Non-RCT
Animal Study
Rigorous JournalEffect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption.
Omeprazole treatment causes protein-bound vitamin B12 malabsorption, and ingestion of an acidic drink improves vitamin B12 absorption in elderly individuals with hypochlorhydria.
Non-RCT
Highly CitedPharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer
Long-term use of omeprazole may induce genomic instability and increase the risk of certain types of cancer, requiring adequate precautions.
Systematic ReviewRigorous JournalOmeprazole Drug Interaction Studies
Omeprazole may partially inhibit the metabolism of drugs metabolized by cytochrome P450 subfamily IIC, but not those metabolized by subfamilies IA, IID, and IIIA.
Literature ReviewHighly CitedA meta‐analysis comparing the efficacy of omeprazole with H2‐receptor antagonists for acute treatment of duodenal ulcer in Asian patients
Omeprazole significantly improves duodenal ulcer healing and symptom relief compared to H2receptor antagonists, even in the presence of adverse prognostic influences.
Meta-AnalysisPharmacokinetic drug interaction profile of omeprazole with adverse consequences and clinical risk management
Omeprazole can cause adverse drug interactions with various medications, requiring enhanced clinical risk management to avoid adverse consequences.
Systematic ReviewRigorous JournalHighly CitedOmeprazole nanoparticles suspension: development of a stable liquid formulation with a view to pediatric administration.
Omeprazole nanoparticles suspension effectively protects mice stomachs against ulcer formation, offering a potential pediatric-friendly liquid pharmaceutical form for treating gastric hypersecretion disorders.
Non-RCTAnimal StudyCan 2-oxoglutarate prevent changes in bone evoked by omeprazole?
Omeprazole treatment negatively affects bone mineralization and cancellous bone, but 2-oxoglutaric acid does not significantly prevent this adverse effect.
Non-RCTAnimal StudyOmeprazole. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peptic ulcer disease and Zollinger-Ellison syndrome.
Omeprazole is a promising drug for rapidly healing peptic ulcers and reducing gastric acid hypersecretion in patients with Zollinger-Ellison syndrome, with potential for major advances in these diseases.
Literature ReviewHighly Cited