Drug finder
Pro Research Analysisby 
Searched over 200M research papers for "drug finder"
Consensus Meter
Comprehensive Drug Discovery and Search Tools
Efficient Pharmacophore Search with Pharmer
Pharmacophore search is a critical aspect of drug discovery, enabling researchers to identify potential drug candidates by matching chemical structures to known pharmacophore models. Pharmer is a novel computational tool that significantly enhances the efficiency of pharmacophore searches. Utilizing the Pharmer KDB-tree and Bloom fingerprints, Pharmer can perform exact searches across nearly two million structures in under a minute, making it more than ten times faster than existing technologies.
SuperDRUG2: A Comprehensive Database for Approved Drugs
SuperDRUG2 serves as an extensive knowledge base for approved and marketed drugs, encompassing 4587 active pharmaceutical ingredients, including small molecules and biological products. This database provides detailed information on chemical structures, regulatory details, indications, drug targets, side effects, physicochemical properties, pharmacokinetics, and drug-drug interactions. A unique feature of SuperDRUG2 is its pharmacokinetics simulation, which allows users to visualize the plasma concentration versus time profile for a given drug dose.
DrugBank: A Resource for In Silico Drug Discovery
DrugBank is a well-curated database that includes 8174 drug entries, such as FDA-approved small-molecule drugs, biotech drugs, nutraceuticals, and experimental drugs. It links these entries to over 4300 non-redundant protein sequences, facilitating drug discovery and development. DrugBank offers tools for finding chemical homologs of potential drug leads and identifying drug targets from newly sequenced tumor samples, integrating cheminformatics with bioinformatics .
DrugSpaceX: Expanding the Chemical Space for Drug Discovery
DrugSpaceX addresses the challenge of exploring the vast drug-like chemical space by providing a database of over 100 million transformed chemical products derived from approved drug molecules. This resource supports virtual screening and offers subsets for ligand identification and optimization, including diversity, drug-like, lead-like, and fragment-like subsets. DrugSpaceX's extensive coverage of three-dimensional chemical space aids in the discovery of novel compounds with desired biological properties.
DrugMAP: Molecular Atlas and Pharma-Information
DrugMAP is a database that systematically depicts the molecular interactions and pharmacological information of over 30,000 drugs and drug candidates. It includes data on the differential expression patterns of more than 5000 interacting molecules across various disease sites, ADME-relevant organs, and physiological tissues. DrugMAP weaves a comprehensive network of over 200,000 interactions, enhancing our understanding of drug pharmacokinetics and pharmacodynamics.
Dtar-Finder: Automated Drug Target Identification in Bacteria
Dtar-Finder is a Perl program designed for the identification and characterization of drug targets in bacteria. It predicts targets that are essential to pathogens and non-homologous to humans, including essential human anti-targets and gut microflora. The program's modules extract drug targets, predict druggability, and assess broad-spectrum potential. Dtar-Finder has demonstrated high specificity and accuracy in identifying potential drug targets.
Enhancing Online Drug Search Systems
Modern software systems for online drug search integrate multiple services and user interfaces to improve search efficiency and effectiveness. These systems often include features such as REST APIs, location-based pharmacy searches, and comprehensive databases that support various search options. By enhancing access to drug-related information, these systems facilitate better decision-making for health consumers .
Conclusion
The landscape of drug discovery and search tools is rapidly evolving, with innovative databases and computational tools significantly enhancing the efficiency and comprehensiveness of drug searches. Resources like Pharmer, SuperDRUG2, DrugBank, DrugSpaceX, DrugMAP, and Dtar-Finder provide invaluable support for researchers and health consumers alike, driving advancements in drug discovery and development.
Sources and full results
Most relevant research papers on this topic