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These studies suggest dyspnea is a subjective experience of breathing discomfort influenced by various factors, including respiratory and cardiopulmonary diseases, neural mechanisms, and emotional factors.
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Dyspnea, often referred to as breathlessness, is defined as a subjective experience of breathing discomfort that consists of qualitatively distinct sensations varying in intensity . This broad definition, endorsed by the American Thoracic Society, highlights the complexity and variability of the symptom, which can manifest differently in each individual .
Dyspnea encompasses a range of respiratory sensations, including chest tightness, the sensation of work or effort in breathing, and air hunger. These sensations are not only uncomfortable but can also significantly impact a patient's quality of life, particularly in those with chronic conditions such as chronic obstructive pulmonary disease (COPD), heart failure, and neuromuscular diseases .
The evaluation of dyspnea requires a systematic approach, including a thorough history, physical examination, and baseline tests of heart and lung function . Given its nonspecific nature, dyspnea can be a diagnostic challenge, often necessitating more sophisticated testing to identify the underlying cause . The differential diagnosis is broad, encompassing respiratory, cardiac, neuromuscular, and even psychiatric conditions .
The sensation of dyspnea is believed to result from a mismatch between the intended respiratory motor output and the actual ventilatory output achieved, a process involving both peripheral and central neural mechanisms. Emotional factors also play a significant role, influencing the sensitivity and threshold of dyspnea perception .
Anxiety and depression are commonly associated with dyspnea, particularly in patients with chronic illnesses such as Parkinson's disease . These emotional responses can exacerbate the sensation of breathlessness, creating a cycle of discomfort and distress .
Accurate diagnosis of the underlying cause of dyspnea is crucial for effective treatment. In cases where the etiology is not immediately apparent, nonspecific treatments may provide some relief, but targeted therapy based on a specific diagnosis is generally more effective .
Recent advancements, such as bedside lung ultrasonography (BLUS), have shown promise in rapidly diagnosing the cause of dyspnea in emergency settings. This non-invasive tool can provide critical information, aiding in the early and accurate treatment of dyspneic patients.
Dyspnea is a complex, multifaceted symptom that requires careful evaluation and management. Understanding its definition, underlying mechanisms, and the broad range of potential causes is essential for providing effective care and improving patient outcomes. Further research into the pathophysiology and treatment of dyspnea will continue to enhance our ability to manage this challenging symptom.
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