Eczema medication cream
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Eczema Medication Cream: A Comprehensive Review
Ceramide-Dominant Moisturizing Cream for Eczema
Ceramide and Skin Barrier Restoration
Ceramide-dominant moisturizing creams have shown promise in restoring the skin barrier in adults with moderate eczema. A study demonstrated that using a ceramide-based cream and cleanser significantly improved skin hydration and reduced transepidermal water loss over 28 days compared to a placebo1. Although the Eczema Area Severity Index (EASI) scores improved in both groups, the difference was not significant between the active and placebo groups at the end of the study. However, patient satisfaction was notably higher in the active group, particularly regarding itch relief and skin smoothness1.
Comparison of Emollient Types in Childhood Eczema
Effectiveness and Acceptability of Emollients
A randomized clinical trial compared the effectiveness of lotions, creams, gels, and ointments in treating childhood eczema. The study found no significant differences in the Patient-Oriented Eczema Measure (POEM) scores among the four types over 16 weeks2. Satisfaction levels varied, with lotions and gels receiving the highest overall satisfaction. The study concluded that all four emollient types were equally effective, and the choice should be based on individual preference and acceptability2.
Mucopolysaccharide Polysulfate (MPS) Cream
Efficacy and Safety
MPS cream has been widely used for non-exudative eczema, showing higher efficacy rates and lower recurrence rates compared to other moisturizers like urea cream or vaseline ointment3. When combined with topical corticosteroids (TCS) or tacrolimus ointment, MPS cream enhanced the overall treatment efficacy and reduced pruritus scores. The safety profile of MPS cream was favorable, with mild skin adverse events reported3.
Topical Pimecrolimus
Alternative to Corticosteroids
Pimecrolimus cream, developed as an alternative to topical corticosteroids, has been effective in treating eczema. Short-term studies showed that pimecrolimus was more effective than a vehicle cream and well-tolerated4. However, it was less effective than moderate and potent corticosteroids and 0.1% tacrolimus. Pimecrolimus also had more withdrawals due to skin burning, indicating a need for careful consideration when prescribing4.
PAC-14028 Cream
Non-Steroidal Treatment
PAC-14028 cream, a non-steroidal treatment, demonstrated efficacy in reducing eczema symptoms with fewer side effects compared to existing creams like pimecrolimus. In a study with 194 adults, the highest concentration of PAC-14028 (1.0%) showed significant improvement in the Investigator's Global Assessment (IGA) scores, with 57.5% of patients achieving almost-clear levels of symptoms5.
Ruxolitinib Cream
JAK1/JAK2 Inhibitor
Ruxolitinib cream, a JAK1/JAK2 inhibitor, has shown rapid and sustained improvements in atopic dermatitis (AD) symptoms. In a phase 2 study, ruxolitinib cream significantly reduced EASI scores and itch within 36 hours, with continued improvement over 12 weeks6. The cream was well-tolerated, making it a potential addition to the topical treatment options for AD6.
Colloidal Oatmeal Cream
Management of Chronic Irritant Hand Eczema
Colloidal oatmeal cream has been effective in managing chronic irritant hand eczema. A study found that patients using colloidal oatmeal cream showed significant improvement in eczema severity and pruritus scores compared to a base cream7. The cream also improved the Dermatology Life Quality Index (DLQI) scores, indicating better quality of life for patients7.
Herbal Creams
Dipotassium Glycyrrhizinate (DPG) HERB Cream
DPG-HERB cream, containing natural anti-inflammatory and antioxidant ingredients, was found to be effective in treating eczema. In a study comparing DPG-HERB with triamcinolone acetonide (TA) cream, both treatments showed significant improvement in eczema symptoms. However, DPG-HERB was less effective in reducing erythema and transepidermal water loss compared to TA cream9.
Halometasone Cream Combined with Simiao Pill
Enhanced Clinical Efficacy
Combining halometasone cream with Simiao pill significantly improved chronic eczema symptoms and reduced serum levels of leukotriene B4 (LTB4) and thymic stromal lymphopoietin (TSLP)10. This combination therapy showed higher clinical efficacy and better quality of life scores compared to halometasone cream alone10.
Conclusion
Various eczema medication creams, including ceramide-dominant moisturizers, MPS cream, pimecrolimus, PAC-14028, ruxolitinib, colloidal oatmeal, DPG-HERB, and halometasone combined with Simiao pill, have demonstrated efficacy in treating eczema. The choice of treatment should consider individual patient needs, preferences, and the specific characteristics of each cream. Further research and high-quality randomized controlled trials are needed to validate these findings and optimize treatment strategies for eczema.
Sources and full results
Most relevant research papers on this topic
A daily regimen of a ceramide‐dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: A randomized trial
A daily regimen of a ceramide-dominant moisturizing cream and cleanser safely restores skin permeability and improves eczema symptoms in adults without serious adverse events.
RCTComparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT.
Lotions, creams, gels, and ointments are equally effective and acceptably used for treating childhood eczema, with no significant difference in effectiveness over 16 weeks.
RCT
Large Human TrialEfficacy and Safety of Mucopolysaccharide Polysulfate Cream for Non-Exudative Eczema: A Systematic Review and Meta-Analysis
MPS cream is an effective and safe treatment for non-exudative eczema with mild and tolerable skin adverse events.
Meta-AnalysisTopical pimecrolimus for eczema.
Topical pimecrolimus is less effective than moderate and potent corticosteroids and 0.1% tacrolimus for treating eczema, with more withdrawals and skin burning.
Meta-AnalysisPAC‐14028 cream for atopic dermatitis
PAC-14028 cream effectively treats eczema symptoms with fewer side-effects than current creams, making it a promising alternative for patients with mild to moderate eczema.
RCT
Rigorous JournalTreatment of Atopic Dermatitis With Ruxolitinib Cream (JAK1/JAK2 Inhibitor) or Triamcinolone Cream.
Ruxolitinib cream significantly reduced atopic dermatitis symptoms and rapidly decreased itch, supporting its potential addition to the topical armamentarium for AD.
RCTLarge Human TrialRigorous Journal
Highly CitedThe Efficacy of Colloidal Oatmeal Cream 1% as Add-on Therapy in the Management of Chronic Irritant Hand Eczema: A Double-Blind Study
Colloidal oatmeal cream 1% effectively reduces eczema severity symptoms and improves quality of life in patients with chronic irritant hand eczema.
RCTRigorous JournalBest emollients for eczema (BEE) – comparing four types of emollients in children with eczema: protocol for randomised trial and nested qualitative study
The study found that a combination of lotion, cream, gel, or ointment may be more effective than individual treatments for children with mild-to-severe eczema.
RCTLarge Human TrialRigorous JournalEfficacy and Safety of Cream Containing Dipotassium Glycyrrhizinate, Vaccinium myrtillius, Epigallocatechin Gallatyl Glucoside, and Tamarindus indica Compared with Triamcinolone Acetonide Cream in Eczema and Psoriasis
DPG-HERB cream is safe and effective in treating eczema, but less effective in psoriasis compared to triamcinolone acetonide cream.
RCTEffect of halometasone cream combined with Simiao pill on the therapeutic effect and expression of serum leukotriene B4 (LTB4) and thymic stromal lymphopoietin (TSLP) in patients with eczema, and the factors influencing its clinical efficacy.
Halometasone cream combined with Simiao pill effectively improves chronic eczema and enhances clinical efficacy, with treatment plan, digestive system symptoms, heavy aching limbs, and damp-heat tongue and pulse being key factors.
Observational Study