Effect of various percentages of chitosan coating on camptothecin loaded mesoporous silica nanopart
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Effects of Various Percentages of Chitosan Coating on Camptothecin-Loaded Mesoporous Silica Nanoparticles
Introduction to Chitosan-Coated Mesoporous Silica Nanoparticles
Chitosan-coated mesoporous silica nanoparticles (MSNs) have garnered significant attention for their potential in drug delivery systems due to their biocompatibility, biodegradability, and ability to enhance drug loading and release profiles. This article explores the effects of varying percentages of chitosan coating on camptothecin-loaded MSNs, focusing on drug loading efficiency, release profiles, and therapeutic efficacy.
Drug Loading Efficiency and Chitosan Coating
The efficiency of drug loading in MSNs can be significantly influenced by the surface modification with chitosan. Studies have shown that chitosan coating enhances the loading capacity of various drugs due to its ability to form a stable matrix around the nanoparticles. For instance, chitosan-glucuronic acid conjugate-coated MSNs demonstrated a high loading capacity for 5-fluorouracil, achieving 172.5 mg/g using the impregnation method. Similarly, chitosan-modified MSNs loaded with methotrexate showed a loading percentage of 12.2%, indicating the positive impact of chitosan on drug encapsulation.
Controlled Release Profiles
Chitosan coating on MSNs also plays a crucial role in controlling the release of the encapsulated drug. The pH-sensitive nature of chitosan allows for targeted and controlled drug release in specific environments. For example, chitosan-glucuronic acid conjugate-coated MSNs exhibited a higher release of 5-fluorouracil in acidic conditions (pH 5.5) compared to neutral conditions (pH 6.8), suggesting a pH-responsive release mechanism. This controlled release is further enhanced in the presence of biological contents, such as rat caecal content, which increases the release rate.
Therapeutic Efficacy and Cytotoxicity
The therapeutic efficacy of chitosan-coated MSNs is significantly improved due to the enhanced drug loading and controlled release properties. Chitosan-coated MSNs loaded with capecitabine showed promising antitumor efficacy with reduced toxicity in colorectal cancer therapy. Additionally, chitosan-coated MSNs used for siRNA delivery demonstrated effective gene silencing and reduced multidrug resistance in cancer cells, highlighting their potential in targeted cancer therapy.
Conclusion
In summary, the percentage of chitosan coating on camptothecin-loaded mesoporous silica nanoparticles significantly affects drug loading efficiency, release profiles, and therapeutic efficacy. Chitosan enhances drug encapsulation, provides controlled and pH-sensitive release, and improves the overall therapeutic outcomes. These findings underscore the potential of chitosan-coated MSNs as a versatile and effective drug delivery system for various therapeutic applications.
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