Eszopiclone side effects

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Eszopiclone Side Effects: A Comprehensive Overview

Common Side Effects of Eszopiclone

Eszopiclone, a non-benzodiazepine hypnotic, is widely used for the treatment of insomnia. However, like all medications, it comes with a range of potential side effects. The most frequently reported side effects include an unpleasant or metallic taste, dry mouth, dizziness, and somnolence Kirkwood2010Liang2019Brielmaier2006. These side effects are generally mild but can be bothersome for some patients.

Side Effects in Elderly Patients

In elderly patients, eszopiclone has been shown to be effective in reducing sleep latency and improving sleep maintenance. However, the elderly are more prone to certain side effects such as unpleasant taste, dry mouth, dizziness, and somnolence Kirkwood2010Liang2019. These side effects are consistent across multiple studies, indicating a clear pattern in this age group.

Side Effects in Non-Elderly Patients

For non-elderly patients, the side effects profile is slightly different. Common adverse effects include infection, pharyngitis, somnolence, unpleasant taste, and dry mouth . These side effects are generally mild and do not significantly impact the overall efficacy of the drug.

Cognitive and Daytime Functioning

Eszopiclone has been associated with some cognitive side effects, particularly in the morning after ingestion. Studies have shown that it can cause residual sedation and impairment of driving performance in the initial morning waking hours . However, these effects are generally mild and do not outweigh the benefits of improved sleep maintenance.

Specific Populations: Schizophrenia and Obstructive Sleep Apnea

In patients with schizophrenia, eszopiclone has been found to be a safe and effective treatment for insomnia, with no significant differences in psychiatric symptoms or discontinuation rates compared to placebo . In patients with obstructive sleep apnea, eszopiclone did not worsen the apnea-hypopnea index (AHI) and actually improved sleep maintenance and efficiency Rosenberg2007Eckert2011.

Conclusion

Eszopiclone is a well-tolerated and effective treatment for insomnia, but it does come with a range of potential side effects. The most common side effects include an unpleasant taste, dry mouth, dizziness, and somnolence. These side effects are generally mild but can vary depending on the patient's age and specific health conditions. Overall, eszopiclone remains a valuable option for those struggling with insomnia, offering significant improvements in sleep quality and maintenance.

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Most relevant research papers on this topic

Management of insomnia in elderly patients using eszopiclone

Eszopiclone is a safe and well-tolerated treatment option for elderly patients with insomnia, reducing sleep latency and improving sleep maintenance and quality of life.

RCTRigorous Journal

2010·

6citations

·Cynthia K. Kirkwood et al.

Nature and Science of Sleep·

DOI

Eszopiclone for the treatment of primary insomnia: a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials.

Eszopiclone is an effective and safe treatment for primary insomnia, particularly in elderly patients, but further large-scale and rigorously designed trials are needed.

Meta-AnalysisRigorous Journal

2019·

28citations

·L. Liang et al.

Sleep medicine·

DOI

Eszopiclone (Lunesta): A New Nonbenzodiazepine Hypnotic Agent

Eszopiclone effectively treats insomnia symptoms and is well-tolerated, with potential side effects including unpleasant taste, headache, and dizziness.

RCT

2006·

18citations

·Benjamin Brielmaier

Baylor University Medical Center Proceedings·

DOI

The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: a double-blind, randomized, placebo-controlled trial.

Eszopiclone is a safe and effective alternative for treating insomnia in patients with schizophrenia, but its effects on cognition require further study.

RCT

2014·

60citations

·C. Tek et al.

Schizophrenia research·

DOI

A pilot study evaluating acute use of eszopiclone in patients with mild to moderate obstructive sleep apnea syndrome.

Eszopiclone did not worsen sleep apnea and improved sleep maintenance and efficiency in patients with mild to moderate obstructive sleep apnea syndrome.

RCTHighly Cited

2007·

101citations

·R. Rosenberg et al.

Sleep medicine·

DOI

Pharmacokinetic evaluation of eszopiclone: clinical and therapeutic implications

Eszopiclone improves sleep maintenance but may cause residual morning sedation and driving performance impairment.

2012·

25citations

·D. Greenblatt et al.

Expert Opinion on Drug Metabolism & Toxicology·

DOI

An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults.

Eszopiclone is a well-tolerated and well-tolerated treatment for transient insomnia in healthy adults, with all doses being more effective than placebo and well-tolerated by patients.

RCTLarge Human Trial

2004·

69citations

·R. Rosenberg et al.

Sleep medicine·

DOI

Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold

Eszopiclone increases the arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnea patients without major hypoxaemia, with greater reductions in apnoea events in those with

RCTHighly Cited

2011·

328citations

·D. Eckert et al.

Clinical science (London, England : 1979)·

DOI

Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder.

Eszopiclone/fluoxetine co-therapy is well-tolerated and associated with rapid, substantial, and sustained sleep improvement, faster onset of antidepressant response, and a greater antidepressant effect.

RCTLarge Human TrialRigorous JournalHighly Cited

2006·

449citations

·M. Fava et al.

Biological psychiatry·

DOI

The acute cognitive effects of zopiclone, zolpidem, zaleplon, and eszopiclone: A systematic review and meta-analysis

A single dose of z-drugs, zolpidem and zopiclone, can cause specific negative effects on verbal memory, attention, speed of processing, and working memory in healthy adults.

Meta-AnalysisHighly Cited

2014·

92citations

·E. Stranks et al.

Journal of Clinical and Experimental Neuropsychology·

DOI

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