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Some studies suggest MSC-derived exosomes can suppress tumors and aid in cancer treatment, while other studies indicate they may promote tumorigenesis, metastasis, and chemoresistance.
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Mesenchymal stem cell (MSC)-derived exosomes have garnered significant attention in cancer research due to their complex roles in tumor progression, metastasis, and potential therapeutic applications. These nano-sized vesicles are involved in intercellular communication and can carry various bioactive molecules, influencing cancer cell behavior in multiple ways.
Dual Role in Tumor Progression:
Tumor Suppression:
Chemoresistance:
Tumor Microenvironment and Metastasis:
Therapeutic Potential:
Diagnostic Biomarkers:
MSC-derived exosomes play a multifaceted role in cancer biology, acting as both promoters and inhibitors of tumor progression. They are involved in key processes such as chemoresistance, metastasis, and tumor suppression. Their potential as drug delivery vehicles and diagnostic biomarkers makes them a promising area of research for future cancer therapies.
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