fibroids cure

Introduction

Uterine fibroids, also known as leiomyomas, are common benign tumors affecting women of reproductive age. They can cause significant symptoms such as heavy menstrual bleeding, pelvic pain, and infertility, impacting the quality of life. Various treatment options, both surgical and non-surgical, are available, but the quest for an ideal cure continues.

Key Insights

Hormonal Treatments

GnRH Analogues and Antagonists: These treatments induce hypoestrogenism, leading to fibroid shrinkage but are limited to short-term use due to side effects like hot flushes and potential rebound growth after cessation .
Selective Progesterone Receptor Modulators (SPRMs): Compounds like Ulipristal acetate and Mifepristone have shown effectiveness in reducing fibroid size and controlling bleeding, though they may have rare liver complications and are not suitable for long-term use .
Other Hormonal Therapies: Progestins, estrogen-progestin combinations, and selective estrogen receptor modulators have limited effectiveness and significant side effects, making them less favorable .

Non-Hormonal and Emerging Treatments

Collagenase Clostridium Histolyticum: This enzyme effectively digests collagen in fibroids, reducing their stiffness and potentially leading to symptom relief and fibroid shrinkage. Clinical trials are needed to confirm its safety and efficacy.
Herbal Preparations: Some studies suggest that certain herbal treatments may reduce fibroid volume, but the evidence is insufficient and of low quality, necessitating further research.

Surgical and Minimally Invasive Options

Myomectomy and Uterine Artery Embolization (UAE): These are common alternatives to hysterectomy for women wishing to preserve fertility. Myomectomy involves surgical removal of fibroids, while UAE blocks blood flow to fibroids, causing them to shrink. Both methods have shown improvements in quality of life and symptom relief .
Preoperative Medical Therapy: Using GnRH analogues or SPRMs before surgery can reduce fibroid size, improve hemoglobin levels, and decrease intraoperative blood loss, making surgery easier and safer.

Conclusion

The management of uterine fibroids involves a range of options, from hormonal therapies and emerging enzymatic treatments to surgical and minimally invasive procedures. While hormonal treatments like GnRH analogues and SPRMs are effective in the short term, they come with limitations and side effects. Emerging treatments like collagenase Clostridium histolyticum show promise but require further validation. Surgical options like myomectomy and UAE remain effective for those seeking to preserve fertility. The ideal treatment would be minimally invasive, effective, safe, and long-lasting, but such a solution is yet to be realized.

Summary

Introduction

Key Insights

Hormonal Treatments

Non-Hormonal and Emerging Treatments

Surgical and Minimally Invasive Options

Conclusion

Sources and full results

Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum.

Highly purified collagenase C histolyticum effectively digests collagen in uterine fibroids, reducing tissue stiffness and potentially offering an alternative treatment option for fibroids.

Uterine fibroids: an update on current and emerging medical treatment options

Long-term medical treatment of uterine fibroids is now possible, especially in premenopausal women, with the use of selective progesterone receptor modulators.

Medical management of fibroids.

The ideal medical therapy for fibroids involves a once-a-day tablet that induces fibroid regression and resolves symptoms rapidly without affecting fertility, but current treatments mainly involve hormonal manipulations.

Fibroid growth and medical options for treatment.

Uterine-sparing treatments like intrauterine progestin delivery and selective progesterone receptor modulators can help control uterine bleeding and reduce fibroid volume, preserving fertility and avoiding unnecessary surgery.

THE TREATMENT OF FIBROIDS OF THE UTERUS

The correct treatment for uterine fibroids is a combination of surgical procedures and radiotherapy, with symptomless fibroids not requiring treatment but removing them for potential degenerative effects.

Herbal preparations for uterine fibroids.

Chinese herbal medicine, particularly Tripterygium wilfordii extract, may reduce uterine fibroid volume and uterine size, but more research is needed.

A randomised trial of treating fibroids with either embolisation or myomectomy to measure the effect on quality of life among women wishing to avoid hysterectomy (the FEMME study): study protocol for a randomised controlled trial

Uterine artery embolization (UAE) may improve quality of life for women with symptomatic uterine fibroids compared to myomectomy, offering a less invasive alternative for those wishing to avoid hysterectomy.

Preoperative medical therapy before surgery for uterine fibroids.

Preoperative medical therapy, such as GnRHa, may reduce uterine and fibroid volume before surgery for uterine fibroids, but long-term use may have unacceptable side effects.

The management of uterine fibroids in women with otherwise unexplained infertility.

Uterine fibroids should be managed surgically, minimizing risks and maximizing pregnancy chances, while minimizing costs and complications.

Modern management of uterine fibroids

Uterine fibroids can cause debilitating symptoms, and new treatment options are needed that are minimally invasive, effective, safe, and less invasive to preserve fertility and preserve the uterus.

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