Full spectrum hemp extract
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Full Spectrum Hemp Extract: Benefits, Safety, and Therapeutic Potential
Introduction to Full Spectrum Hemp Extract
Full spectrum hemp extract (FSHE) is derived from the Cannabis sativa plant and contains a wide range of cannabinoids, terpenes, and other phytochemicals, including cannabidiol (CBD) and tetrahydrocannabinol (THC) in trace amounts. Unlike CBD isolates, FSHE includes the full array of compounds found in the hemp plant, which may work synergistically to enhance therapeutic effects, a phenomenon known as the "entourage effect"1.
Safety and Regulatory Considerations
The safety of FSHE has been a topic of significant interest, especially following the 2018 United States Agriculture Improvement Act, which legalized hemp with less than 0.3% THC content1. Post-marketing surveillance of FSHE products, such as those by CV Sciences, has shown a low incidence of adverse events (AEs). Out of approximately five million units sold, only 0.03% of users reported AEs, with gastrointestinal issues being the most common for orally ingested products and dermatological symptoms for topically applied products. Importantly, no evidence of liver toxicity was found, indicating that FSHE is generally safe and well-tolerated at recommended doses2.
Therapeutic Applications and Efficacy
Pain Management
FSHE has shown promise in managing both acute and chronic pain. Studies have demonstrated that FSHE can alleviate mechanical allodynia in neuropathic pain models, with significant pain relief observed within hours of administration7. Additionally, combining FSHE with other compounds like palmitoylethanolamide (PEA) has been found to produce greater-than-additive effects in reducing pain-related behaviors, suggesting potential for enhanced therapeutic strategies5.
Anti-Inflammatory Effects
The anti-inflammatory properties of FSHE are well-documented. Research indicates that FSHE can modulate the transcription of inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-10 (IL-10), thereby reducing inflammation in conditions like chronic constriction injury5. This makes FSHE a valuable candidate for treating inflammatory diseases.
Behavioral and Cognitive Effects
While FSHE has therapeutic benefits, it can also induce behavioral changes. Studies on animal models have shown that FSHE can lead to cognitive dysfunction and impaired motor skills, which are linked to specific metabolomic changes in the blood4. Identifying these biomarkers can help in diagnosing and managing these side effects more effectively.
Innovative Delivery Systems
To enhance the bioavailability and therapeutic efficacy of FSHE, innovative delivery systems are being developed. For instance, microencapsulation techniques using chitosan-coated alginate have been shown to improve the stability and bioaccessibility of FSHE, ensuring a more controlled release of cannabinoids3. Similarly, melt-printed polymeric microdepots have been designed to provide sustained release of FSHE, maintaining elevated serum levels of cannabinoids for extended periods and improving therapeutic outcomes in models of convulsion6.
Conclusion
Full spectrum hemp extract offers a promising therapeutic option for a variety of conditions, including pain, inflammation, and potentially other health issues. Its safety profile is generally favorable, with minimal adverse effects reported. However, the potential for behavioral side effects necessitates careful monitoring and further research. Innovative delivery systems are enhancing the efficacy and stability of FSHE, paving the way for more effective treatments. As research continues, FSHE may become a cornerstone in the management of various health conditions, leveraging the full therapeutic potential of the hemp plant.
Sources and full results
Most relevant research papers on this topic
Differentiating Full-Spectrum Hemp Extracts from CBD Isolates: Implications for Policy, Safety and Science
Full-spectrum hemp extracts contain a complex phytochemical matrix, distinguishing them from CBD isolates for phytochemical, toxicological, and regulatory purposes.
Post Marketing Safety of Plus CBD™ Products, a Full Spectrum Hemp Extract: A 2-Year Experience
Plus CBDTM products, a full spectrum hemp extract, are safe and well-tolerated at recommended doses, with no evidence of liver toxicity.
Observational StudyChitosan-Coated Alginate Microcapsules of a Full-Spectrum Cannabis Extract: Characterization, Long-Term Stability and In Vitro Bioaccessibility
Chitosan-coated alginate microcapsules of a full-spectrum cannabis extract show medium-high bioaccessibility (55-77%) and long-term stability, making them suitable for designing full-spectrum oral formulations.
Metabolomic Fingerprint of Behavioral Changes in Response to Full-Spectrum Cannabis Extracts
Full-spectrum cannabis extract-induced behavioral changes in rats are linked to increased serum concentrations of amino acids phenylalanine and long-chain acylcarnitines, potentially aiding in rapid diagnosis of cognitive impairment.
RCT
Animal StudyPalmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain.
Hemp oil extract and palmitoylethanolamide (PEA) show synergistic anti-nociceptive effects, providing greater than additive relief for acute and chronic pain in mouse models.
Non-RCTAnimal Study
Rigorous JournalFull-Spectrum Cannabis Extract Microdepots Support Controlled Release of Multiple Phytocannabinoids for Extended Therapeutic Effect
Melt-printed polymeric microdepots for full-spectrum cannabis extract administration can sustainably release multiple phytocannabinoids for extended therapeutic effects, potentially offering a new treatment option.
Non-RCTAnimal StudyThe Therapeutic Effectiveness of Full Spectrum Hemp Oil Using a Chronic Neuropathic Pain Model
Full-spectrum hemp oil effectively reduces chronic neuropathic pain sensitivity in mice, with a peak reversal effect at 4 hours.
Non-RCTAnimal StudyPost Marketing Efficacy and Safety Study of BOHECO Peace (Full Spectrum Hemp Leaf Extract Based Ayurvedic Proprietary Medicine) for the Management of Pain
BOHECO PEACE, a full spectrum hemp leaf extract based Ayurvedic proprietary medicine, effectively reduces chronic pain and has no serious adverse reactions when used at prescribed doses.
The molecular mechanisms that underpin the biological benefit of full spectrum cannabis extract in the treatment of neuropathic pain and inflammation.
Full-spectrum cannabis extracts, not just purified cannabinoids, may provide more effective treatment for neuropathic pain and inflammation due to their diverse molecular mechanisms.
Literature ReviewEffect of Broad-Spectrum Hemp Extract on Neurobehavioral Activity on the Immobilization Stress-Induced Model in Sprague Dawley Rats
Broad-spectrum hemp extract inhibits oxidative stress biomarkers and improves certain behavioral parameters in stressed rats, potentially benefiting stress and anxiety management.
Non-RCTAnimal Study