Generic name for hydrochlorothiazide
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Generic Name for Hydrochlorothiazide: An Overview
Introduction to Hydrochlorothiazide
Hydrochlorothiazide (HCTZ) is a widely used diuretic medication primarily prescribed for the treatment of hypertension and mild to moderate edema. It belongs to the thiazide class of diuretics and is considered highly effective by healthcare professionals2.
Pharmaceutical Equivalence and Quality Control
Several studies have evaluated the pharmaceutical equivalence and quality of hydrochlorothiazide formulations. One study assessed the quality of various pharmaceutical formulations containing HCTZ through quality control and thermal characterization tests. It was found that some generic versions did not meet the required pharmaceutical equivalence standards, particularly due to incompatibility with excipients like lactose and mannitol1. Another study compared the dissolution profiles of reference and generic HCTZ medicines, revealing that while most generics met the required standards, some did not achieve the necessary plasma levels for effective absorption2.
Bioequivalence and Interchangeability
The bioequivalence of generic HCTZ products has been a subject of extensive research. A meta-analysis confirmed the interchangeability of several generic HCTZ products, ensuring that they meet the necessary bioequivalence criteria. This interchangeability is crucial for maintaining therapeutic efficacy and safety when patients switch between different generic brands4. Additionally, a comparative study of a brand-name and a generic triamterene-hydrochlorothiazide combination product found no significant differences in clinical efficacy, safety, or bioavailability, further supporting the reliability of generic formulations3.
Quality Concerns in Generic Hydrochlorothiazide
Despite the general acceptance of generic HCTZ products, quality concerns persist. A study conducted in Salvador, Brazil, highlighted that while most generic and similar HCTZ medicines complied with pharmacopoeial standards, some generics failed to meet the assay specifications, raising concerns about their quality and reliability5. This underscores the importance of rigorous quality control measures to ensure the safety and efficacy of generic medications.
Conclusion
Hydrochlorothiazide is a critical medication for managing hypertension and edema, with numerous generic versions available. While most generics meet the required standards for pharmaceutical equivalence and bioequivalence, some quality concerns remain. Continuous monitoring and stringent quality control are essential to ensure that all generic HCTZ products provide the same therapeutic benefits as their brand-name counterparts.
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Most relevant research papers on this topic
Quality Evaluation of Pharmaceutical Formulations Containing Hydrochlorothiazide
The generic drug Lab 2 and compounded drugs Lab 5 and Lab 6 are not pharmaceutical equivalents, with lactose and mannitol potentially explaining the lack of equivalence.
ESTUDOS DE EQUIVALÊNCIA FARMACÊUTICA E PERFIL DE DISSOLUÇÃO COMPARATIVO DE MEDICAMENTOS CONTENDO HIDROCLOROTIAZIDA
Hydrochlorothiazide (HCTZ) tablets from different brands show pharmaceutical equivalence and dissolution profile similarity, but only G3 shows a dissolution profile that may impair interchangeability with the reference medicine.
Comparative efficacy and bioequivalence of a brand-name and a generic triamterene-hydrochlorothiazide combination product.
Patients with nonlabile essential hypertension can safely and effectively switch from brand-name Dyazide to a generic triamterene-hydrochlorothiazide product without loss of therapeutic efficacy or toxicity.
RCTMeta-analysis for bioequivalence studies: interchangeability of generic drugs and similar containing Hydrochlorothiazide is possible but not with Enalapril Maleate.
Interchangeability between generic drugs containing Hydrochlorothiazide is possible, but not with Enalapril Maleate, potentially changing the effectiveness of the product.
Meta-AnalysisQuality evaluation and dissolution profile of hydrochlorothiazide tablets available in Salvador-BA, Brazil
Hydrochlorothiazide tablets in Salvador, Bahia, Brazil, meet pharmacopoeial standards, except for the generic brand, which has content out of specification.
Hydrochlorothiazide Use and Skin Cancer: A Mohs Surgeon's Concern.
Hydrochlorothiazide use is associated with an increased risk of skin cancer, particularly in patients with a history of cutaneous carcinoma and hypertension.
Very Rigorous JournalHydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability.
Chlorthalidone and hydrochlorothiazide are considered interchangeable thiazide diuretics, but their pharmacokinetic and pharmacodynamic differences may cause differences in cardiovascular outcomes.
Systematic Review
Highly CitedCharacterization of hydrochlorothiazide in solid formulations
X-ray powder diffraction and Rietveld method effectively characterize hydrochlorothiazide's Form I and crystalline excipients lactose monohydrate and sodium lauryl sulfate in solid formulations, revealing excipients not listed in package insert
Half a century of hydrochlorothiazide: facts, fads, fiction, and follies.
Hydrochlorothiazide is an inappropriate first-line drug for hypertension due to its lack of efficacy, poor adherence, and poor overall safety.
Meta-AnalysisEfficacy of Low-Dose Chlorthalidone and Hydrochlorothiazide as Assessed by 24-h Ambulatory Blood Pressure Monitoring.
Low-dose chlorthalidone, 6.25 mg daily, effectively reduces 24-hour blood pressure in patients with essential hypertension, while low-dose hydrochlorothiazide monotherapy is not appropriate due to its short duration of action.
RCTVery Rigorous JournalHighly Cited