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These studies suggest that gluten can increase inflammation by weakening intestinal barrier function, altering immune responses, and affecting gut microbiota, particularly in individuals with celiac disease or non-celiac gluten sensitivity.
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Gluten, a protein found in wheat and related grains, has been implicated in various inflammatory conditions, particularly in individuals with celiac disease (CD) and non-celiac gluten sensitivity (NCGS). This synthesis aims to consolidate findings from multiple research papers to understand how gluten affects inflammation.
Gluten and Intestinal Inflammation in Celiac Disease:
Mechanisms of Gluten-Induced Inflammation:
Immune Response and Gluten:
Gluten and Gut Microbiota:
Gluten significantly contributes to inflammation through various mechanisms, including altering intestinal permeability, activating immune cells, and disrupting gut microbiota. These effects are particularly pronounced in individuals with celiac disease and non-celiac gluten sensitivity, where gluten exacerbates both local and systemic inflammation. Effective management of these conditions often requires strict adherence to a gluten-free diet, although some inflammation may persist.
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