Hab1c levels
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Summary
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These studies suggest that obese male adolescents with lower socioeconomic status have higher HbA1c levels and that the ARKRAY HA-8190V instrument is effective for HbA1c measurement.
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Prevalence and Evaluation of HbA1c Levels
Prevalence of Elevated HbA1c Levels in Adolescents
High HbA1c Levels in Brazilian Adolescents
The prevalence of elevated glycated hemoglobin (HbA1c) levels among Brazilian adolescents has been a significant concern. A comprehensive study involving 37,804 adolescents aged 12-17 years revealed that the mean HbA1c level was 5.4% (36 mmol/mol), with 20.5% of the adolescents exhibiting elevated HbA1c levels (≥5.7%, 39 mmol/mol). The study highlighted several demographic disparities:
- Gender Differences: Elevated HbA1c levels were more prevalent in males (23.6%) compared to females (17.5%).
- Ethnic Disparities: Adolescents with black skin color had a higher prevalence (27.6%) of elevated HbA1c levels compared to those with white skin color (16.9%).
- Socioeconomic Factors: Those attending public schools showed a higher prevalence (21.6%) of elevated HbA1c levels compared to their counterparts in private schools (16.7%).
- Nutritional Status: Obese adolescents had the highest prevalence of elevated HbA1c levels (29.7%), followed by those with normal weight (19.3%) and overweight adolescents (19.7%).
These findings underscore the need for targeted interventions, particularly for obese male adolescents of lower socioeconomic status, to prevent the onset of diabetes.
Evaluation of HbA1c Measurement Instruments
Performance of the ARKRAY HA-8190V Instrument
The ARKRAY HA-8190V instrument has been evaluated for its efficacy in measuring HbA1c levels, which is crucial for monitoring and diagnosing diabetes. The instrument demonstrated excellent precision and minimal bias:
- Precision: The coefficient of variation (CV) was ≤0.8% in IFCC SI units (≤0.6% NGSP) at 34 and 102 mmol/mol levels (5.3% and 11.5% NGSP).
- Bias: The bias was -0.1 mmol/mol (-0.01% NGSP) at a concentration of 50 mmol/mol (6.7% NGSP), although there was a significant slope compared to target values, resulting in a bias of -1.0 and 0.9 mmol/mol (-2.0% and 0.9% NGSP) at the 30 and 70 mmol/mol (4.9% and 8.6% NGSP) concentration levels.
- Interference: The instrument showed less than 3 mmol/mol (0.3% NGSP) interference in the presence of common Hb variants (AS, AC, AE, AD) and elevated HbA2 and HbF concentrations at a 50 mmol/mol (6.7% NGSP) concentration.
The ARKRAY HA-8190V's analytical performance is commendable, particularly in terms of precision and its ability to accurately quantify HbA1c in the presence of common hemoglobin variants.
Conclusion
The prevalence of elevated HbA1c levels among Brazilian adolescents, particularly among obese males of lower socioeconomic status, highlights the urgent need for targeted diabetes prevention strategies. Concurrently, the ARKRAY HA-8190V instrument has proven to be a reliable tool for HbA1c measurement, ensuring accurate monitoring and diagnosis of diabetes. These insights are crucial for both public health initiatives and clinical practices aimed at managing and preventing diabetes.
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