High cholesterol medication list
Pro Research Analysisby 
Searched over 200M research papers
Consensus Meter
High Cholesterol Medication List
Introduction to High Cholesterol and Its Risks
High cholesterol, particularly elevated low-density lipoprotein (LDL) cholesterol, is a significant risk factor for cardiovascular diseases such as coronary heart disease (CHD) and stroke. Managing cholesterol levels is crucial for reducing these risks, and various medications are available to help achieve this goal.
Statins: The Primary Cholesterol-Lowering Medications
Statins are the most commonly prescribed medications for lowering cholesterol. They work by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver. Statins are highly effective in reducing LDL cholesterol levels and have been shown to significantly decrease the risk of cardiovascular events. Common statins include simvastatin, atorvastatin, and rosuvastatin.
Fibrates: Targeting Triglycerides and HDL Cholesterol
Fibrates are another class of medications used to manage cholesterol levels, particularly in patients with high triglycerides and low high-density lipoprotein (HDL) cholesterol. Fibrates, such as gemfibrozil, work by activating peroxisome proliferator-activated receptors (PPARs), which increase the oxidation of fatty acids and reduce triglyceride levels. They also modestly increase HDL cholesterol levels. Studies have shown that fibrates can reduce the risk of major coronary events by approximately 25% .
Niacin: Increasing HDL Cholesterol
Niacin, also known as vitamin B3, is used to increase HDL cholesterol levels and lower triglycerides. It works by inhibiting the breakdown of fats in adipose tissue, which reduces the amount of free fatty acids available for the liver to produce triglycerides and LDL cholesterol. Niacin has been shown to increase HDL cholesterol levels by up to 16% and reduce the risk of major coronary events by 27%. However, its use is often limited by side effects such as flushing.
CETP Inhibitors: A New Approach to Raising HDL Cholesterol
Cholesteryl ester transfer protein (CETP) inhibitors are a newer class of drugs designed to raise HDL cholesterol levels. CETP inhibitors, such as torcetrapib and evacetrapib, work by inhibiting the transfer of cholesteryl esters from HDL to other lipoproteins, thereby increasing HDL cholesterol levels. While CETP inhibitors have shown promise in raising HDL cholesterol, their impact on reducing cardiovascular events remains uncertain. Some studies have shown that CETP inhibitors can significantly increase HDL cholesterol levels, but their effect on cardiovascular outcomes is still under investigation .
Bile Acid Sequestrants: Reducing LDL Cholesterol
Bile acid sequestrants, such as cholestyramine, work by binding to bile acids in the intestine, preventing their reabsorption. This forces the liver to use more cholesterol to produce bile acids, thereby reducing the amount of cholesterol in the blood. Bile acid sequestrants are effective in lowering LDL cholesterol levels but are often used in combination with other cholesterol-lowering medications due to their gastrointestinal side effects.
Combination Therapies: Enhancing Efficacy
Combination therapies, such as using statins with ezetimibe or fibrates, can provide additional benefits in managing cholesterol levels. Ezetimibe works by inhibiting the absorption of cholesterol from the intestine, complementing the action of statins. Studies have shown that combining ETC-1002 with ezetimibe can significantly reduce LDL cholesterol levels more than ezetimibe alone.
Conclusion
Managing high cholesterol is essential for reducing the risk of cardiovascular diseases. A variety of medications, including statins, fibrates, niacin, CETP inhibitors, bile acid sequestrants, and combination therapies, are available to help achieve optimal cholesterol levels. Each medication has its unique mechanism of action and benefits, and the choice of therapy should be tailored to the individual patient's needs and risk profile.
Sources and full results
Most relevant research papers on this topic