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Some studies suggest that cancer patients die from infections and organ failure, while other studies highlight the importance of palliative care, home care, and addressing symptoms to improve quality of life and support for patients and families.
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Cancer remains a leading cause of death worldwide, with millions of individuals succumbing to the disease each year. The World Health Organization (WHO) estimates that by 2020, over 10 million people globally will die from cancer annually. Despite advancements in treatment, the journey towards the end of life for cancer patients is often fraught with complex symptoms and emotional challenges.
Cancer patients can die from the primary cancer (index-cancer) or other causes (nonindex-cancer). The risk of death from the primary cancer varies significantly depending on the type of cancer. For instance, patients with liver, pancreas, esophagus, lung, and brain cancers have a higher likelihood of dying from their primary cancer. Conversely, those with cancers of the colorectum, bladder, kidney, endometrium, breast, and prostate often die from noncancer causes, such as heart disease.
Infections are a leading cause of death among cancer patients, accounting for 47% of deaths in a reviewed study. Common fatal infections include pneumonia, septicemia, and peritonitis, often caused by gram-negative bacteria like E. coli and Pseudomonas spp.. Organ failure is another significant cause, responsible for 25% of deaths, followed by infarction, hemorrhage, and carcinomatosis.
Patients with advanced cancer experience a multitude of symptoms that severely impact their quality of life. Common symptoms include pain, fatigue, anxiety, depression, breathlessness, insomnia, nausea, constipation, and anorexia. These symptoms are often interrelated and can exacerbate each other, making management challenging.
The emotional and social aspects of living with advanced cancer are profound. Patients frequently deal with anxiety, depression, and spiritual concerns, which can be as debilitating as physical symptoms. Effective communication and support from healthcare providers and family members are crucial in addressing these issues.
While many cancer patients express a preference to die at home, the majority end up dying in hospitals due to various factors, including the severity of symptoms and lack of adequate home care support . Factors such as low functional status, strong family support, and intensive home care increase the likelihood of dying at home.
The place of death significantly affects the quality of life of cancer patients and the mental health of their caregivers. Patients who die in hospitals or intensive care units (ICUs) experience more physical and emotional distress compared to those who die at home with hospice care. Additionally, caregivers of patients who die in hospitals are at a higher risk of developing psychiatric disorders, such as posttraumatic stress disorder and prolonged grief disorder.
Dying with cancer involves a complex interplay of physical symptoms, emotional distress, and social factors. While advancements in palliative care have improved the management of symptoms, there remains a need for better support systems to allow more patients to die in their preferred setting, typically at home. Addressing these needs can enhance the quality of life for patients and reduce the psychological burden on their caregivers.
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