How does brufen work
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How Does Brufen Work?
Mechanism of Action of Brufen (Ibuprofen)
Brufen, commonly known as ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX). This enzyme is crucial in the biosynthesis of prostaglandins, which are lipid compounds that play a key role in inflammation and pain. By blocking COX, Brufen reduces the production of prostaglandins, thereby alleviating pain and inflammation .
Analgesic Effects in Pain Management
Post-Partum Pain Relief
Brufen has been shown to be effective in managing post-partum pain. In a study comparing ibuprofen to dextropropoxyphene, ibuprofen provided superior pain relief at various time intervals, including one hour, one and a half hours, four hours, and five hours post-administration. The overall effectiveness over a 12-hour period was significantly higher for ibuprofen, with minimal side effects reported.
Rheumatic Diseases
In the treatment of rheumatic conditions, Brufen has demonstrated significant efficacy. A multi-centre study comparing Brufen to Butacote (phenylbutazone) and a placebo found that Brufen was effective in reducing morning stiffness and the need for supplementary analgesics. Although Butacote was preferred for overall pain relief, Brufen still showed substantial benefits.
Antipyretic Effects in Fever Management
Pediatric Fever
Brufen is also effective in reducing fever in children. Studies have shown that Brufen suspension can quickly reduce fever and maintain normal body temperature for up to eight hours, outperforming other treatments like SM aminopyrine and paracetamol in terms of speed and duration of effect . This makes it a preferred choice for pediatric fever management due to its quick action and longer-lasting effects.
Upper Respiratory Infections
In cases of fever due to upper respiratory infections, Brufen has been found to be more effective than conventional defervescence methods. It not only reduces fever more quickly but also maintains the reduced temperature for a longer period, making it a reliable option for managing fever in children .
Anti-Inflammatory Effects in Other Conditions
Cervical Spondylosis
Brufen has been used in combination with traditional Chinese medicine to treat cervical spondylosis. This combination therapy has shown significant improvements in pain and coma symptoms, with a high overall effectiveness rate and minimal adverse reactions.
Hepatic Fibrosis in Schistosomiasis
In experimental studies on rabbits with schistosomiasis-induced hepatic fibrosis, Brufen has been observed to reduce the expression of type I and II collagen mRNA and TIMP-1 mRNA while increasing MMP-1 mRNA. This suggests that Brufen can help resist the development of hepatic fibrosis by modulating collagen deposition.
Conclusion
Brufen (ibuprofen) is a versatile NSAID that effectively manages pain, inflammation, and fever through the inhibition of COX enzymes and subsequent reduction in prostaglandin synthesis. Its applications range from post-partum pain relief and pediatric fever management to the treatment of rheumatic diseases and cervical spondylosis. With its quick action and sustained effects, Brufen remains a valuable medication in various clinical settings.
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