How long does it take for lisinopril to start working
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These studies suggest that lisinopril starts working early in the treatment of acute myocardial infarction and remains effective for at least 6 months, also effectively reducing blood pressure in hypertensive patients without affecting heart rate.
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How Long Does It Take for Lisinopril to Start Working?
Introduction to Lisinopril and Its Uses
Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor commonly used to treat hypertension, congestive heart failure, and acute myocardial infarction (AMI). It works by relaxing blood vessels, which helps to lower blood pressure and improve blood flow.
Onset of Action in Hypertension
For patients with hypertension, lisinopril begins to reduce blood pressure within 2 hours of oral administration. The peak effect is typically observed around 6 hours after dosing, and the antihypertensive effect lasts for at least 24 hours. This makes lisinopril effective for once-daily dosing, providing a smooth and gradual reduction in blood pressure without significantly affecting heart rate or cardiovascular reflexes.
Early Benefits in Acute Myocardial Infarction
In the context of acute myocardial infarction, lisinopril has been shown to provide measurable survival benefits within 1 to 2 days of starting treatment. The GISSI-3 trial, which included over 19,000 patients, demonstrated that when lisinopril is administered within 24 hours of symptom onset and continued for 6 weeks, it significantly reduces the risk of mortality and severe left ventricular dysfunction . This early benefit is attributed to lisinopril's ability to attenuate the detrimental effects of left ventricular remodeling, along with its cardioprotective and vasculoprotective actions.
Long-Term Effects and Continued Benefits
The benefits of lisinopril extend beyond the initial treatment period. Even after the 6-week treatment course is completed, the positive effects on survival and ventricular function persist. At 6 months, patients who received lisinopril showed a lower incidence of mortality and severe ventricular dysfunction compared to those who did not receive the treatment . This suggests that the early intervention with lisinopril has lasting benefits, likely due to its impact on the remodeling processes of the heart .
Conclusion
Lisinopril starts to work within 2 hours for hypertension, with peak effects around 6 hours. In the case of acute myocardial infarction, significant benefits in terms of survival and ventricular function can be observed within 1 to 2 days of starting treatment. These benefits continue to be evident even after the treatment is stopped, highlighting the importance of early intervention with lisinopril in suitable patients.
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