How Long Does Lisinopril Stay In Your System

How Long Does Lisinopril Stay in Your System?

Pharmacokinetics of Lisinopril

Absorption and Bioavailability

Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, has an oral bioavailability of approximately 25% ± 4%, which remains unaffected by food intake. This means that the drug is absorbed into the bloodstream at a consistent rate regardless of whether it is taken with or without food.

Half-Life and Steady State

The drug has a complex elimination profile. The accumulation half-life of lisinopril averages around 12.6 hours, while the terminal serum half-life is approximately 40 hours. This discrepancy is due to the drug's pharmacokinetic properties, which include its elimination via the kidneys without undergoing metabolism. Lisinopril is primarily excreted through glomerular filtration, tubular secretion, and tubular reabsorption. Steady-state concentrations of the drug are typically achieved after two daily doses, meaning that the drug reaches a consistent level in the bloodstream within 48 hours of regular dosing.

Elimination from the Body

Renal Excretion

Lisinopril is not metabolized by the liver and is eliminated unchanged through the kidneys. This renal excretion involves multiple processes, including glomerular filtration and tubular secretion and reabsorption. Given its terminal half-life of 40 hours, it can take several days for lisinopril to be completely cleared from the system. Specifically, it may take around 5 to 7 days for the drug to be eliminated from the body, considering the general rule that it takes about 5 half-lives for a drug to be fully excreted.

Clinical Implications

Duration of Effects Post-Treatment

Interestingly, the effects of lisinopril can extend beyond its physical presence in the body. In a study involving patients with acute myocardial infarction, early treatment with lisinopril showed a reduction in mortality and severe left ventricular dysfunction that persisted even six months after the treatment was stopped . This suggests that the benefits of lisinopril may last longer than the drug itself remains in the system.

Conclusion

Lisinopril has a terminal half-life of approximately 40 hours and is primarily eliminated through the kidneys. It generally takes about 5 to 7 days for the drug to be fully cleared from the body. However, the therapeutic effects of lisinopril, particularly in the context of acute myocardial infarction, may persist for several months after discontinuation of the drug.

Summary

Not a yes or no question