How much cbd for insomnia
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Optimal CBD Dosage for Insomnia: A Research Synthesis
Introduction to CBD and Insomnia
Insomnia is a prevalent condition that significantly impacts health and daily functioning. Cannabidiol (CBD), a non-psychoactive component of cannabis, has gained attention as a potential treatment for insomnia. This article synthesizes current research to determine the optimal CBD dosage for managing insomnia.
Single-Dose Studies: High-Dose CBD and Sleep Outcomes
Several studies have explored the effects of a single high dose of CBD combined with THC on sleep. A study involving 20 participants with chronic insomnia disorder tested a single dose of 200 mg CBD and 10 mg THC. The results showed a significant reduction in total sleep time (TST) and time spent in REM sleep, with no significant change in wake after sleep onset (WASO)1 2 4. Despite these reductions, there were no next-day impairments in cognitive performance, alertness, or simulated driving performance2 4.
Chronic Dosing: Daily CBD Supplementation
Research on chronic CBD dosing indicates potential benefits for insomnia. A study with 30 participants using a daily dose of 150 mg CBD for two weeks showed a significant reduction in insomnia severity, although CBD did not outperform placebo in this trial3. Another study using a combination of CBD and terpenes (300 mg CBD daily) for 28 days found an increase in restorative sleep stages (slow wave sleep and REM sleep) without affecting total sleep time7.
Comparative Studies: CBD vs. Placebo
Comparative studies have provided mixed results. A systematic review of 34 studies found that CBD, either alone or in combination with THC, improved insomnia symptoms in a significant portion of participants. However, the review highlighted the need for more research using validated subjective and objective measures specifically in insomnia patients6. Another study using a CBD/THC oil (10 mg THC and 15 mg CBD) over two weeks showed improved sleep quality and increased light sleep duration, with 60% of participants no longer classified as clinical insomniacs by the end of the intervention9.
Safety and Adverse Effects
The safety profile of CBD appears favorable. Studies reported mild, non-serious adverse events such as dry mouth, drowsiness, and fatigue, with no significant withdrawal symptoms upon discontinuation2 4 5. High doses of CBD (up to 600 mg) did not induce psychotropic or toxic effects, although some participants reported somnolence5.
Conclusion
Current research suggests that high doses of CBD (150-600 mg) may be effective in reducing insomnia severity and improving sleep quality. However, the optimal dosage may vary, and further research is needed to establish standardized dosing guidelines. Combining CBD with THC may enhance sleep benefits, but the effects on REM sleep and total sleep time should be considered. Overall, CBD shows promise as a safe and effective treatment for insomnia, but more rigorous studies are required to confirm these findings and determine the best therapeutic approach.
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Most relevant research papers on this topic
Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) for chronic insomnia disorder (‘CANSLEEP’ trial): protocol for a randomised, placebo-controlled, double-blinded, proof-of-concept trial
A single dose of an oral cannabis-based medicine (ETC120) containing 10 mg THC and 200 mg CBD may improve sleep and daytime function in individuals with chronic insomnia disorder.
RCT
Rigorous Journal0371 Acute effects of cannabinoids in insomnia disorder: a randomised, placebo-controlled trial using high-density EEG
A single dose of 200 mg CBD and 10 mg THC reduced total sleep time and suppressed REM sleep in insomnia patients without impairing cognitive function, alertness, or simulated driving performance.
RCTO049 Insomnia severity and cognitive performance following two weeks’ nightly supplementation with 150mg Cannabidiol (CBD) for primary insomnia
Daily CBD supplementation (150mg) reduced insomnia severity from moderate to subthreshold levels without affecting higher-order cognitive performance.
RCTO006 Acute effects of combined cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC) in insomnia disorder: A randomised, placebo-controlled trial using high-density EEG
A single dose of 200 mg CBD and 10 mg THC reduced total sleep time and REM sleep time in insomnia patients without impairing next-day cognitive performance or alertness.
RCTHypnotic and Antiepileptic Effects of Cannabidiol
Cannabidiol (CBD) shows no psychotropic or toxic effects, improves sleep in insomniacs, and shows potential in treating epilepsy refractory to current antiepileptic drugs.
RCT
Highly CitedUse of Cannabidiol in the Management of Insomnia: A Systematic Review.
CBD alone or with equal quantities of THC may be beneficial in alleviating insomnia symptoms, but more validated research is needed before definitive conclusions can be made.
Systematic ReviewA Cannabidiol/Terpene Formulation That Increases Restorative Sleep in Insomniacs: A Double-Blind, Placebo-controlled, Randomized, Crossover Pilot Study
An oral CBD-terpene formulation can increase slow wave sleep and REM sleep in insomniacs without affecting total sleep time and without causing adverse events.
RCTCannabidiol (CBD) and Insomnia : Literature review
Short-term use of medium to high doses of CBD may improve insomnia, but combined use with THC may decrease slow wave sleep.
Systematic ReviewRigorous JournalMedicinal cannabis improves sleep in adults with insomnia: a randomised double‐blind placebo‐controlled crossover study
Entoura-10:15 medicinal cannabis oil is well-tolerated and effectively improves sleep quality and time in adults with insomnia, with 60% of participants no longer classified as clinical insomniacs after 2 weeks.
RCTRigorous JournalCannabidiol in Humans—The Quest for Therapeutic Targets
High-dose oral CBD may have therapeutic effects for social anxiety disorder, insomnia, and epilepsy, but may cause mental sedation.
Systematic ReviewHighly Cited