How much metformin for weight loss
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Metformin Dosage for Weight Loss: Insights from Research
Introduction to Metformin and Weight Loss
Metformin, a medication primarily used to treat type 2 diabetes, has been observed to promote weight loss in various populations, including those without diabetes. This article synthesizes findings from multiple studies to determine the effective dosages of metformin for weight loss.
Effective Dosages of Metformin for Weight Loss
Dosage Comparison in Obese Women with PCOS
A study comparing different doses of metformin (1500 mg/day and 2550 mg/day) in obese women with polycystic ovary syndrome (PCOS) found that both doses resulted in significant weight loss. The obese subgroup showed a dose-dependent relationship, with weight reductions of 1.5 kg and 3.6 kg for the 1500 mg and 2550 mg groups, respectively. However, the morbidly obese group experienced similar weight loss (around 3.8 kg) regardless of the dose.
Short-Term Effects in Overweight or Obese Patients with T2DM
In a 16-week trial, overweight or obese patients with type 2 diabetes mellitus (T2DM) treated with 1500 mg/day of metformin lost an average of 2.96 kg. This was significantly less than the weight loss observed with polyethylene glycol loxenatide (PEG-Loxe), a glucagon-like peptide 1 receptor agonist, which resulted in a 7.52 kg reduction.
Weight Loss in Insulin-Resistant Children
A study on severely obese, insulin-resistant children aged 6-12 years treated with 1000 mg of metformin twice daily for six months showed a significant decrease in body weight (3.38 kg) and BMI. This suggests that even lower doses can be effective in younger populations.
Systematic Review and Meta-Analysis Findings
A systematic review and network meta-analysis identified that for adolescents, 1000 mg/day of metformin for three months was most suitable, while for adults, 3000 mg/day for six months was more effective. This analysis highlights the variability in optimal dosages based on age and treatment duration.
Dose-Dependent Appetite Suppression
Research on non-insulin-dependent diabetes mellitus (NIDDM) patients indicated that metformin reduces calorie intake in a dose-dependent manner. A higher dose of 1700 mg/day was more effective in suppressing appetite and inducing weight loss compared to 850 mg/day.
Real-Life Outpatient Setting
In a real-life outpatient setting, patients treated with up to 2500 mg/day of metformin experienced an average weight loss of 5.8 kg over six months. This study also noted that patients with severe insulin resistance lost more weight compared to those who were insulin sensitive.
Conclusion
Metformin has been shown to be effective for weight loss across various populations and dosages. Higher doses, such as 2550 mg/day, may offer greater weight reduction in certain groups, while lower doses like 1000 mg/day can still be effective, particularly in younger individuals. The optimal dosage may vary based on individual characteristics such as age, insulin resistance, and the presence of conditions like PCOS. Further research is needed to refine these recommendations and explore long-term effects.
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