How to get rid of wheezing
Pro Research Analysisby 
Searched over 200M research papers
Consensus Meter
Effective Strategies to Get Rid of Wheezing
Wheezing, characterized by a high-pitched whistling sound during breathing, is a common respiratory issue, especially in children. It can be triggered by various factors, including viral infections, allergens, and asthma. Here, we synthesize the latest research on effective strategies to manage and reduce wheezing episodes.
Inhaled Corticosteroids for Wheezing Management
Continuous and Intermittent Use
Inhaled corticosteroids (ICS) are a cornerstone in the management of wheezing, particularly in children. Studies have shown that both continuous and intermittent administration of ICS can significantly reduce the risk of virus-induced wheezing episodes. This treatment is especially beneficial for children with recurrent wheezing triggered by viral infections.
Phenotype-Specific Responses
The effectiveness of ICS can vary depending on the child's wheezing phenotype. For instance, children with atopic wheezing (associated with allergies) tend to benefit more from ICS, experiencing fewer exacerbations. However, the early use of ICS, such as fluticasone propionate, does not necessarily prevent the development of asthma or improve long-term lung function.
Leukotriene Modifying Agents
Leukotriene modifying agents, such as montelukast, have shown promise in managing wheezing episodes, particularly in children with episodic (viral) wheeze. These agents can be started at the onset of viral symptoms to help reduce the severity and duration of wheezing episodes .
Bacterial Lysate Therapy
Bacterial lysates, which are preparations of bacterial components, have been found to reduce the frequency of wheezing episodes and asthma exacerbations in children. This therapy works by modulating the immune system, enhancing T-helper (Th)1-cell activation, and suppressing Th2-cell responses. The use of bacterial lysates has also been associated with a reduction in antibiotic use and shorter duration of wheezing episodes.
Anticholinergic Agents
Ipratropium Bromide
Anticholinergic agents like ipratropium bromide, when combined with beta2-agonists, can be effective in treating acute wheezing episodes in infants. This combination has been shown to reduce the need for additional treatments and improve clinical scores significantly . However, the evidence supporting the uncritical use of anticholinergics alone is limited.
Tiotropium Bromide
Intermittent use of tiotropium bromide has also been explored as a treatment for episodic wheezing. Research indicates that tiotropium bromide can increase the proportion of episode-free days compared to other treatments, making it a potential alternative for managing wheezing in young children.
Nutritional Supplements
Vitamin D and Fish Oil
Early supplementation with certain nutrients, such as vitamin D and fish oil, has been investigated for their potential protective effects against wheezing and asthma. Regular vitamin D supplementation during infancy may help prevent respiratory tract infections, although its effect on wheezing and asthma prevention is less clear. Similarly, early introduction of fish in the diet has shown some protective effects against the development of wheezing and asthma.
Probiotics
Probiotics, particularly when used alongside inhaled steroids, may offer additional benefits in managing recurrent wheezing. Probiotic supplementation has been associated with reduced wheezing episodes and favorable changes in immune response markers, such as increased levels of IL-10 and IL-12.
Conclusion
Managing wheezing effectively requires a multifaceted approach tailored to the individual's specific triggers and phenotypes. Inhaled corticosteroids, leukotriene modifying agents, bacterial lysates, and anticholinergic agents all play crucial roles in reducing wheezing episodes. Additionally, nutritional supplements like vitamin D and probiotics may offer supplementary benefits. Ongoing research and personalized treatment strategies are essential to optimize outcomes for individuals suffering from wheezing.
Sources and full results
Most relevant research papers on this topic