How to raise wbc
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Strategies to Raise White Blood Cell (WBC) Count
Medical Interventions for Increasing WBC Count
All-Trans Retinoic Acid (ATRA) and Chemotherapy
One effective method to increase WBC counts, particularly in patients with acute promyelocytic leukemia (APL), involves the use of all-trans retinoic acid (ATRA) combined with chemotherapy. Studies have shown that this combination not only improves the complete response rate but also significantly reduces the cumulative incidence of relapse in patients with high WBC counts1. This approach has been particularly successful in reducing early deaths and relapses, thereby improving overall survival rates in APL patients with elevated WBC counts1.
Lifestyle and Hormonal Influences on WBC Count
Impact of Pregnancy and Oral Contraceptives
Pregnancy is known to cause leucocytosis, which is an increase in the number of white blood cells. This is a natural response and can be beneficial in boosting the immune system during pregnancy3. Additionally, the use of oral contraceptives has been reported to raise WBC counts, although this effect is less pronounced with low estrogen preparations3. These hormonal changes can be leveraged to manage WBC levels in specific populations.
Monitoring and Predictive Value of WBC Count
Predictive Value in Coronary Interventions
A raised WBC count has been identified as a significant predictor of long-term mortality in patients undergoing percutaneous coronary interventions (PCI). This suggests that monitoring WBC counts can provide valuable insights into patient prognosis and help in tailoring post-procedural care to improve outcomes2. Elevated WBC counts are associated with increased inflammation, which plays a critical role in the progression of coronary artery disease2.
Conclusion
Raising WBC counts can be achieved through a combination of medical treatments, such as ATRA and chemotherapy, and lifestyle factors, including pregnancy and the use of oral contraceptives. Monitoring WBC counts is also crucial in predicting long-term outcomes in patients with coronary artery disease. These strategies collectively contribute to better management and improved survival rates in patients with conditions associated with low WBC counts.
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Most relevant research papers on this topic
Improved outcome of acute promyelocytic leukemia with high WBC counts over the last 15 years: the European APL Group experience.
Acute promyelocytic leukemia with high WBC counts has significantly improved over the years, with fewer early deaths and fewer relapses, due to better initial supportive care and combined maintenance treatment.
RCT
Highly CitedImpact of preprocedural white blood cell count on long term mortality after percutaneous coronary intervention: insights from the EPIC, EPILOG, and EPISTENT trials
A raised pre-procedural white blood cell count in patients undergoing percutaneous coronary intervention is associated with an increased risk of long-term death, suggesting inflammation plays a key role in coronary artery disease.
Highly CitedTOTAL AND DIFFERENTIAL LEUCOCYTE COUNT
Normal leucocyte count values vary between individuals, with factors like age, sex, race, pregnancy, smoking, and oral contraceptives influencing these values.
White blood cell (WBC) counting analysis in blood smear images using various color segmentation methods
Using S color component of HSV and nucleus-based detection for white blood cell counting in blood smear images provides the highest segmentation accuracy and 96.56% counting accuracy.
Highly CitedClinical and Experimental Studies on the Efficacy of WBC - raising Mixture on Post - chemotherapy Leukopenia
A WBC-raising mixture effectively raises white blood cells, improves immunity, and effectively treats post-chemotherapy leukopenia in patients.
RCT
Animal StudyEffects of recombinant canine granulocyte colony-stimulating factor on white blood cell production in clinically normal and neutropenic dogs.
Recombinant canine granulocyte colony-stimulating factor effectively stimulates white blood cell production and function in dogs, with doses varying based on the cause of neutropenia.
Non-RCTAnimal StudyWhite blood cell count is associated with macro- and microvascular complications in chinese patients with type 2 diabetes.
Elevated white blood cell count, even within the normal range, is associated with both macro- and microvascular complications in type 2 diabetes patients.
Observational Study
Rigorous JournalHighly CitedEffects of bacteria and yeast on WBC counting in three automated hematology counters
Yeast may influence peripheral blood smear results when yeast concentration is unusually high, with results differing among analyzers and yeast species.
In Vitro StudyNon-electrical powered continuous cell concentration for enumeration of residual white blood cells in WBC-depleted blood using a viscoelastic fluid.
The viscoelastic microfluidic device effectively concentrates residual white blood cells in WBC-depleted blood without external power source, improving blood transfusion safety.
Prolonged Administration of Leaf Extract of Ocimum gratissimum Reduces RBC, PCV and Platelet Count but Increases Total WBC and Lymphocyte Counts in Rats
Aqueous leaf extract of Ocimum gratissimum reduces RBC, PCV, platelet, and neutrophil counts but increases total WBC and lymphocyte counts in rats.
RCTAnimal Study