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Some studies suggest inhaled corticosteroids, leukotriene modifying agents, and azithromycin can reduce wheezing, while other studies highlight bacterial lysate therapy as a promising add-on treatment.
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Wheezing, characterized by a high-pitched whistling sound during breathing, can be distressing and requires prompt attention. Here, we synthesize the latest research on immediate interventions to alleviate wheezing.
Inhaled corticosteroids, such as fluticasone propionate, are commonly used to manage wheezing. A study involving young children demonstrated that early use of inhaled fluticasone propionate did not significantly alter the natural progression of asthma or wheezing later in childhood. However, it was effective in controlling symptoms during the treatment period. This suggests that while inhaled corticosteroids may not provide long-term prevention, they can offer immediate relief from wheezing episodes.
Bacterial lysate therapy has shown promise in reducing wheezing episodes and asthma exacerbations, particularly in children. This therapy works by modulating the immune system, enhancing T-helper (Th)1-cell activation, and suppressing Th2-cell responses. A meta-analysis revealed that bacterial lysates significantly decreased the frequency and duration of wheezing episodes, making it a potential add-on therapy for immediate wheezing relief.
For wheezing triggered by viral infections, early administration of azithromycin has been found to reduce the severity of lower respiratory tract illnesses in children. This antibiotic can be particularly effective in managing severe wheezing episodes associated with viral infections.
Leukotriene modifying agents may also play a role in managing wheezing, especially in children with specific phenotypes. These agents help reduce inflammation and bronchoconstriction, providing relief from wheezing symptoms.
Immediate relief from wheezing can be achieved through various interventions. Inhaled corticosteroids like fluticasone propionate are effective for symptom control, while bacterial lysate therapy offers immunomodulatory benefits that reduce wheezing episodes. Additionally, early use of azithromycin and leukotriene modifying agents can be beneficial, particularly for viral-induced wheezing. These strategies, tailored to individual needs, can provide prompt and effective relief from wheezing.
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