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These studies suggest that microglia play a crucial and complex role in Alzheimer's disease progression, involving both protective and harmful effects, with potential therapeutic targets identified in their genetic and functional profiles.
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Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline. Microglia, the resident immune cells of the central nervous system, play a crucial role in the pathogenesis and progression of AD. Understanding the dynamic states of microglia during AD progression is essential for developing targeted therapeutic strategies.
Genetic Influence on Microglial Function:
Microglial Activation and Neuroinflammation:
Microglial Heterogeneity:
Microglial Dysfunction and Disease Progression:
Therapeutic Potential:
Microglia play a multifaceted role in Alzheimer's disease, influenced by genetic factors and characterized by diverse activation states. While they can protect against AD by clearing amyloid-β and supporting neuronal health, their chronic activation and dysfunction contribute to neuroinflammation and disease progression. Understanding the complex dynamics of microglial states in AD is crucial for developing effective therapeutic interventions.
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